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胃癌转移相关lncRNA的研究进展
作者:黄珊1 2  于天源3  樊红1 
单位:1. 东南大学医学院 遗传与发育生物学系, 江苏 南京 210009;
2. 东南大学医学院 临床医学专业, 江苏 南京 210009;
3. 四川大学吴玉章学院, 四川大学电子信息学院 电子信息专业, 四川 成都 610065
关键词:长链非编码RNA 胃癌 转移 上皮细胞间质转化 生物标志物 综述 
分类号:Q752
出版年·卷·期(页码):2017·36·第五期(856-860)
摘要:

非编码RNA (non-coding RNA,ncRNA)是指基因组中无蛋白质产物的一类RNA,占基因组转录本近98%。长链非编码RNA (long non-coding RNA,lncRNA)是指长度超过200 nt的一类非编码RNA,其表达及功能异常与机体的生长发育及疾病密切相关。近年来不断涌现的研究结果显示,lncRNA分子在各种恶性肿瘤中异常表达,与肿瘤的发生发展密切相关。胃癌是我国常见恶性肿瘤,其病因学的研究结果提示了lncRNA的重要作用。作者仅对近期研究提示与胃癌转移相关lncRNA的研究进行综述,并简述这些lncRNA在胃癌临床应用价值及其在肿瘤研究中的生物信息学方法。

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