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炎症反应与肿瘤微环境对前列腺癌作用机制的研究进展
作者:苏欢  陈明 
单位:东南大学附属中大医院 泌尿外科, 江苏 南京 210009
关键词:前列腺癌 炎症反应 肿瘤微环境 综述 
分类号:R737.25;R364.5
出版年·卷·期(页码):2017·36·第五期(847-851)
摘要:

自20世纪90年代以来,大量的流行病学、临床、实验证据显示,炎症细胞在肿瘤细胞中的浸润,对于肿瘤的发生发展起着重要作用。浸润于肿瘤中的巨噬细胞、肥大细胞、中性粒细胞、T细胞、B细胞及其相关亚群,其释放的如肿瘤坏死因子(TNF)、表皮细胞生长因子(EGF)、血管内皮生长因子(VEGF)、成纤维细胞生长因子2(FGF2)等细胞因子一方面通过重构细胞外基质(ECM)、介导上皮间质转分化(EMT)促进了肿瘤的发生、生长及转移,另一方面募集了骨髓源干细胞。后者和肿瘤干细胞可分化为上皮细胞、间质肌成纤维细胞等细胞亚群,促进肿瘤生长和血管形成,同时,骨髓源干细胞对于细胞毒性T淋巴细胞(CTL)、自然杀伤(NK)细胞的抑制作用可使肿瘤细胞在免疫机制中存活。在前列腺癌中,炎症反应与前列腺增殖性炎性萎缩(PIA)密切相关。大量的前列腺穿刺病理标本发现,前列腺癌组织及癌旁组织往往伴有前列腺炎症和炎症细胞的浸润。本文作者就肿瘤微环境中免疫细胞组分、炎症反应与前列腺癌发生发展的关系最新研究进展作一综述。

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