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肺腺癌中PLK1的异常表达及其临床病理意义
作者:徐艳1 2  沈小星2  刘标3  饶秋3  时姗姗3  王璇3  何燕3  黄培林1 
单位:1. 东南大学医学院 病理与病理生理学系, 江苏 南京 210009;
2. 解放军杭州疗养院 特勤疗养科, 浙江 杭州 310007;
3. 南京总医院 病理科, 江苏 南京 210002
关键词:肺腺癌 PLK1 表达 临床病理特征 KRAS突变 三阴性 预后 
分类号:R741.02
出版年·卷·期(页码):2017·36·第五期(804-810)
摘要:

目的:探讨肺腺癌中PLK1的异常表达及临床病理意义。方法:免疫组化SP法检测266例I-IV期肺腺癌中PLK1的表达并分析其与临床病理特征、预后、TTF1和p53表达及分子学表型的关系。结果:PLK1过表达与吸烟(P<0.05)、转移/复发(P<0.01)及高临床分期(P<0.05)显著相关。常见于胶样腺癌(87.5%)、浸润性黏液腺癌(86.7%)和实体型腺癌(81.1%)(P<0.01)。在泌黏液型腺癌(73.1%)中发生率显著高于非泌黏液型腺癌(57.5%)(P<0.05)。PLK1过表达与KRAS突变、p53表达及三阴性肺腺癌显著相关(P<0.01),与TTF1表达、EGFR突变和EML4-ALK融合基因无显著相关性。肺腺癌中PLK1过表达与预后相关(P<0.01)且为独立预后因素(HR=2.235,P<0.01)。结论:PLK1过表达在部分肺腺癌的发病和进展过程中发挥重要作用。

Objective:To explore the abnormal expression and the clinicopathologic significance of Polo-like kinase 1 (PLK1) in adenocarcinoma (ADC) of the lung. Methods:The expressions of PLK1 in 266 patients with stage I-IV lung ADC were detected by immunohistochemistry (IHC) (SP method). The correlations with PLK1 expression and the clinicopathological characteristics, the expression of TTF1 and p53 and the molecular phenotype were further analyzed. Results:There was a positive correlation with PLK1 overexprssion and smoking history (P<0.05), metastesis/recurrence (P<0.01), and higher stage (P<0.05). PLK1 overexpression was more frequently found in colloid ADCs (87.5%), invasive mucinous ADCs (86.7%) and solid ADCs (81.1%) (P<0.01). PLK1 overexprssion was more common in mucin-product ADCs than in non mucin-product ADCs (P<0.05). PLK1 overexpression was significiantly correlated with KRAS mutation (P<0.01), p53 protein expression (P<0.01) and triple negative ADCs (P<0.01), other than TTF1 expression, EGFR mutation or EML4-ALK fusion. In lung ADCs, PLK1 overexpression was strongly associated with prognosis (P<0.01), and played as an independent prognostic role (HR=2.235, P<0.01). Conclusion:PLK1 overexpression possibly plays an important role in pathogenesis and evolution of a subset of lung ADCs.

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