江苏某高校教工高尿酸血症及相关性分析-东南大学学报医学版

江苏某高校教工高尿酸血症及相关性分析

单位：1. 东南大学医院, 江苏南京 210018;
2. 东南大学公共卫生学院, 江苏南京 210009

分类号：R181.36

出版年·卷·期（页码）：2017·36·第五期（785-788）

摘要：

目的：探讨江苏某高校教工高尿酸血症（HUA）患病率及相关危险因素。方法：以参加某高校2016年5月至11月体检的教工为研究对象，进行各项体检及生化指标测定。结果：该群体HUA患病率为20.8%，男性显著高于女性（P<0.01）。HUA患者的年龄、体质量指数、腰围等8项指标均高于尿酸正常者，而估算的肾小球滤过率低于尿酸正常者（P<0.05）。多因素Logistic回归模型显示男性、肥胖、腹型肥胖、高血压、肾功能严重受损、低高密度脂蛋白血症与血尿酸水平呈正相关（P<0.05）。HUA患者合并3项及以上心血管病危险因素的比例高于尿酸正常者（P<0.05）。结论：男性、肥胖、腹型肥胖、高血压、肾功能严重受损、低高密度脂蛋白血症是HUA独立危险因素，而HUA合并心血管病危险因素有聚集性，应采取综合措施尽早干预HUA发生发展。

Objective:To investigate the prevalence and risk factors of hyperuricemia (HUA) among faculty in a university in Jiangsu Province. Methods:Physical examinations and blood tests of the faculty of a university were collected during May to October 2016. Results:The overall prevalence of HUA was 20.8%, and the prevalence in male was higher than that in female(P<0.01). Some typical features of HUA patients among the faculty, including the age,body mass index, waist, systolic pressure, diastolic pressure, fasting blood glucose, triglyceride, high-density lipoprotein(HDL) were higher than the normal ones and had lower renal dysfunction(P<0.05). Multivariate Logistic regression models showed that male gender, obesity, hypertension, abdomen obesity, renal dysfunction and hypo-HDL had positive correlation with HUA (P<0.05). The faculty who had HUA were much more easily to have three or more cardiovascular risk factors compared with the normal faculty (P<0.05). Conclusion:Male gender, obesity, hypertension, abdomen obesity, renal dysfunction and hypo-HDL are independent risk factors of HUA. Comprehensive measures should be taken to prevent the occurrence and development of HUA。

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