目的：探讨脑源性神经营养因子（BDNF）在冠状动脉粥样硬化性心脏病（简称冠心病）患者血清中的表达状况以及相关性研究。方法：56例健康对照（Con组）及131例冠心病患者（CAD组）纳入研究。ELISA法检测所有被研究者的血清BDNF水平。结果：CAD组与Con组血清BDNF水平比较差异有统计学意义（P<0.01）。亚组分析：将CAD组分为稳定型冠心病组（SCAD组，n=81）与急性冠脉综合征组（ACS组，n=50），并计算Grace危险评分，血清BDNF水平在ACS组显著升高（P<0.01）；ACS组血清BDNF水平随Grace危险评分的增加而降低，呈显著负相关。结论：BDNF在冠心病患者中升高，尤其是在ACS患者中显著升高；并且BDNF可以作为ACS患者远期风险的预测指标。

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