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外周和门静脉血中循环肿瘤细胞在胰腺癌诊治中的研究现状及应用前景
作者:王洋1  周家华2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学 附属中大医院, 江苏 南京 210009
关键词:循环肿瘤细胞 胰腺癌 门静脉血 检测 预后 综述 
分类号:R44;R735.9
出版年·卷·期(页码):2017·36·第四期(673-677)
摘要:

胰腺癌是恶性程度最高的肿瘤之一,早期诊断率及5年生存率低。目前胰腺癌循环肿瘤细胞检测技术繁多,其灵敏度和特异性不尽相同,外周血和门静脉血中循环肿瘤细胞数量及标志物表达对胰腺癌的诊断、预后具有提示作用。本文作者对外周和门静脉血中循环肿瘤细胞在胰腺癌诊治中的研究现状作一综述。

参考文献:

[1] JEMAL A,SIEGEL R,WARD E,et al.Cancer statistics[J].CA Cancer J Clin,2009,59(4):225-249.
[2] PLEBANI M,BASSO D,DEL F G,et al.Clinical utility of TPS,TPA and CA 19-9 measurement in pancreatic cancer[J].Oncology,1993,50(6):436-440.
[3] ALIXPANABIERES C,PANTEL K.The circulating tumor cells:liquid biopsy of cancer[J].Klin Lab Diagn,2014(4):60.
[4] PANTEL K,ALIXPANABIÉRES C,RIETHDORF S.Cancer micrometastases[J].Nat Rev Clin Oncol,2009,6(6):339-351.
[5] KHOJA L,BACKEN A,SLOANE R,et al.A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker[J].Br J Cancer,2011,106(3):508-516.
[6] CHAPMAN C G,WAXMAN I.Portal-vein blood samples as a new diagnostic entity for pancreatic cancer[J].Expert Rev Gastroenterol Hepatol,2016,10(6):665-667.
[7] BOBEK V,GURLICH R,ELIASOVA P,et al.Circulating tumor cells in pancreatic cancer patients:enrichment and cultivation[J].World J Gastroenterol,2014,20(45):17163-17170.
[8] VONA G,SABILE A,LOUHA M,et al.Isolation by size of epithelial tumor cells:a new method for the immunomorphological and molecular characterization of circulatingtumor cells[J].Am J Pathol,2000,156(1):57-63.
[9] CHINEN L T,MELLO C A,ABDALLAH E A,et al.Isolation,detection,and immunomorphological characterization of circulating tumor cells (CTCs) from patients with different types of sarcoma using isolation by size of tumor cells:a window on sarcoma-cell invasion[J].Onco Targets Ther,2014,7(5):1609-1617.
[10] HOFMAN V,LONG E,ILIE M,et al.Morphological analysis of circulating tumour cells in patients undergoing surgery for non-small cell lung carcinoma using the isolation by size of epithelial tumour cell (ISET) method[J].Cytopathology,2012,23(1):30-38.
[11] DESITTER I,GUERROUAHEN B S,BENALIFURET N,et al.A new device for rapid isolation by size and characterization of rare circulating tumor cells[J].Anticancer Res,2011,31(2):427-441.
[12] ALLARD W J,MATERA J,MILLER M C,et al.Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases[J].Clin Cancer Res,2004,10(20):6897-6904.
[13] CATENACCI D V,CHAPMAN C G,XU P,et al.Acquisition of portal venous circulating tumor cells from patients with pancreaticobiliary cancers by endoscopic ultrasound[J].Gastroenterology,2015,149(7):1794-1803.
[14] ARNOLETTI J P,ZHU X,ALMODOVAR A J,et al.Portal venous blood circulation supports immunosuppressive environment and pancreatic cancer circulating tumor cell activation.[J].Pancreas,2016,46(1):116-123.
[15] PORUK K E,RD V V,SAUNDERS T,et al.Circulating tumor cell phenotype predicts recurrence and survival in pancreatic adenocarcinoma[J].Ann Surg,2016,264(6):1073-1081.
[16] YANG G,ZHU Y,ZHANG Z,et al.Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization[J].J Exp Clin Cancer Res,2016,35(1):1-8.
[17] LI Y,ZHANG X,GE S,et al.Clinical significance of phenotyping and karyotyping of circulating tumor cells in patients with advanced gastric cancer[J].Oncotarget,2014,5(16):6594-6602.
[18] SERGEANT G,ROSKAMS T,van PELT J,et al.Perioperative cancer cell dissemination detectedwith a real-time RT-PCR assay for EpCAM is not associated with worse prognosis in pancreaticductal adenocarcinoma[J].BMC Cancer,2011,11(47):1471-1478.
[19] de ALBUQUERQUE A,KUBISCH I,BREIER G,et al.Multimarker gene analysis of circulating tumor cells in pancreatic cancer patients:a feasibility study[J].Oncology,2012,82(1):3-10.
[20] NAGRATH S,SEQUIST L V,MAHESWARAN S,et al.Isolation of rare circulating tumour cells in cancer patients by microchip technology[J].Nature,2007,450(7173):1235-1239.
[21] WEN T Y,HSUN-CHUAN K,BE-ING H,et al.A high circulating tumor cell count in portal vein predicts liver metastasis from periampullary or pancreatic cancer:a high portal venous CTC count predicts liver metastases[J].Medicine,2016,95(16):e3407.
[22] RHIM A D,THEGE F I,SANTANA S M,et al.Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesions[J].Gastroenterology,2014,146(3):647-651.
[23] KURIHARA T,ITOI T,SOFUNI A,et al.Detection of circulating tumor cells in patients with pancreatic cancer:a preliminary result[J].J Hepatobiliary Pancreat Sci,2008,15(2):189-195.
[24] JIAO L R,APOSTOLOPOULOS C,JACOB J,et al.Unique localization of circulating tumor cells in patients with hepatic metastases[J].J Clin Oncol,2009,27(36):6160-6165.
[25] KIM M Y,OSKARSSON T,ACHARYYA S,et al.Tumor self-seeding by circulating cancer cells[J].Cell,2009,139(7):1315-1326.

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