S100钙结合蛋白A13是S100蛋白家族中的一员。目前研究显示S100A13结构特殊，可能具有独特的生物学功能，其表达与甲状腺肿瘤、黑色素瘤、肝癌、肺癌等有关。S100A13可能成为某些肿瘤的预后标志物和靶向治疗的靶点。本文作者就S100A13与肿瘤的研究进展作一综述。

[1] BRESNICK A R,WEBER D J,ZIMMER D B.S100 proteins in cancer[J].Nat Rev Cancer,2015,15(2):96-109.
[2] LECLERC E,HEIZMANN C W.The importance of Ca²⁺/Zn²⁺ signaling S100 proteins and RAGE in translational medicine[J].Fron Biosci(Schol Ed),2011,3:1232-1262.
[3] HERMANN A,DONATO R,WEIGER T M,et al.S100 calcium binding proteins and ion channels[J].Front Pharmacol,2012,3:67.
[4] DONATO R,CANNON B R,SORCI G,et al.Functions of S100 proteins[J].Curr Mol Med,2013,13(1):24-57.
[5] NASSER M W,ELBAZ M,AHIRWA R,et al.Conditioning solid tumor microenvironment through inflammatory chemokines and S100 family proteins[J].Cancer Lett,2015,365(1):11-22.
[6] WICKI R,SCHAFER B W,ERNE P,et al.Characterization of the human and mouse cDNAs coding for S100A13,a new member of the S100 protein family[J].Biochem Biophys Res Commun,1996,227(2):594-599.
[7] SHAO X,LI C,FERNANDEZ I,et al.Synaptotagmin-syntaxin interaction:the C2 domain as a Ca²⁺-dependent electrostatic switch[J].Neuron,1997,18(1):133-142.
[8] LI M,ZHANG P F,PAN X W,et al.Crystal structure study on human S100A13 at 2.0 A resolution[J].Biochem Biophys Res Commun,2007,356(3):616-621.
[9] RIDINGER K,SCHAFER B W,DURUSSEL I,et al.S100A13.Biochemical characterization and subcellular localization in different cell lines[J].J Biol Chem,2000,275(12):8686-8694.
[10] SHISHIBORI T,OYAMA Y,MATSUSHITA O,et al.Three distinct anti-allergic drugs,amlexanox,cromolyn and tranilast,bind to S100A12 and S100A13 of the S100 protein family[J].Biochem J,1999,338(Pt 3):583-589.
[11] CAO R X,YAN B,YANG H L,et al.Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells[J].J Formos Med Assoc,2010,109(9):632-640.
[12] LANDRISCINA M,BAGALA C,MANDINOVA A,et al.Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress[J].J Biol Chem,2001,276(27):25549-25557.
[13] SIVARAJA V,KUMAR T K,RAJALINGAM D,et al.Copper binding affinity of S100A13,a key component of the FGF-1 nonclassical copper-dependent release complex[J].Biophys J,2006,91(5):1832-1843.
[14] KATHIR K M,GAO L,RAJALINGAM D,et al.NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1)[J].Biochim Biophys Acta,2010,1798(2):297-302.
[15] MOHAN S K,RANI S G,YU C.The Heterohexameric Complex Structure,a Component in the Non-classical Pathway for Fibroblast Growth Factor 1(FGF1) Secretion[J].J Biol Chem,2010,285(20):15464-15475.
[16] HAYRABEDYAN S,KYURKCHIEV S,KEHAYOV I.FGF-1 and S100A13 possibly contribute to angiogenesis in endometriosis[J].J Reprod Immunol,2005,67(1-2):87-101.
[17] RANI S G,SEPURU K M,YU C.Interaction of S100A13 with C2 domain of receptor for advanced glycation end products (RAGE)[J].Biochim Biophys Acta,2014,1844(9):1718-1728.
[18] ZHONG J,LIU C,CHEN Y J,et al.The association between S100A13 and HMGA1 in the modulation of thyroid cancer proliferation and invasion[J].J Transl Med,2016,14:80.
[19] MARTINEZ-AGUILAR J,CLIFTON-BLIGH R,MOLLOY M P.A multiplexed,targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours[J].BMC Cancer,2015,15:199.
[20] DINETS A,PERNEMALM M,KJELLIN H,et al.Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions[J].PLoS One,2015,10(5):e0126472.
[21] 刘畅,曹仁贤,钟警,等.甲状腺癌组织中S100A13、FGF-1表达及意义[J].实用癌症杂志,2009,24(1):19-21,25.
[22] WELINDER C,JONSSON G,INGVAR C,et al.Feasibility study on measuring selected proteins in malignant melanoma tissue by SRM quantification[J].J Proteome Res,2014,13(3):1315-1326.
[23] AZIMI A,PERNEMALM M,FROSTVIK STOLT M,et al.Proteomics analysis of melanoma metastases:association between S100A13 expression and chemotherapy resistance[J].Br J Cancer,2014,110(10):2489-2495.
[24] MASSI D,LANDRISCINA M,PISCAZZI A,et al.S100A13 is a new angiogenic marker in human melanoma[J].Mod Pathol,2010,23(6):804-813.
[25] PIERCE A,BARRON N,LINEHAN R,et al.Identification of a novel,functional role for S100A13 in invasive lung cancer cell lines[J].Eur J Cancer,2008,44(1):151-159.
[26] 张鹤,黄朋,部先文,等.钙结合蛋白S100A13在肝癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2011,18(2):206-210.
[27] LANDRISCINA M,SCHINZARI G,di LEONARDO G,et al.S100A13,a new marker of angiogenesis in human astrocytic gliomas[J].J Neurooncol,2006,80(3):251-259.
[28] SIEGEL R L,MILLER K D,JEMAL A.Cancer Statistics,2017[J].CA Cancer J Clin,2017,67(1):7-30.