>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
兔椎间盘退变体内模型建立的最新进展
作者:俞佳斌1  王宸2  王善正2  陈翔溆2  马良彧1  贾军1  郭玉冬2  马雪倩3 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 骨科, 江苏 南京 210009;
3. 浙江大学 医学院, 浙江 杭州 310029
关键词:椎间盘退变  模型建立 综述 
分类号:R-332;R681.53
出版年·卷·期(页码):2017·36·第四期(656-660)
摘要:

椎间盘退变模型是研究椎间盘退变的病因和治疗的基础。目前兔是最适合构建椎间盘退变模型的动物,它具有操作简单、饲养方便、价格合适、可重复性好等优点。兔椎间盘退变体内模型建立的方式主要分为异常应力模型、机械损伤模型以及化学损伤模型三大类。本文作者综述了最近关于兔的椎间盘退变体内模型的建立方法,并介绍各个模型退变的特点,以便于后期实验能更好的来选择椎间盘退变模型。

参考文献:

[1] ZHOU R P,ZHANG Z M,WANG L,et al.Establishing a disc degeneration model using computed tomography-guided percutaneous puncture technique in the rabbit[J].J Surg Res,2013,181(2):65-74.
[2] SCHOLLUM M L,APPLEYARD R C,LITTLE C B,et al.A detailed microscopic examination of alterations in normal anular structure induced by mechanical destabilization in an ovine model of disc degeneration[J].Spine(Phila Pa 1976),2010,35(22):1965-1973.
[3] CHIANG C J,CHENG C K,SUN J S,et al.The effect of a new anular repair after discectomy in intervertebral disc degeneration:an experimental study using a porcine spine model[J].Spine,2011,36(10):761-769.
[4] BERGKNUT N,RUTGES J P,KRANENBURG H J,et al.The dog as an animal model for intervertebral disc degeneration?[J].Spine,2011,37(5):351-358.
[5] 劳杨骏,徐涛涛,杨笑奇,等.小鼠椎间盘退变模型的构建策略[J].中国中医急症,2015,24(10):1783-1786.
[6] TAN S L,AHMAD T S,SELVARATNAM L,et al.Isolation,characterization and the multi-lineage differentiation potential of rabbit bone marrow-derived mesenchymal stem cells[J].J Anat,2013,222(4):437-450.
[7] IATRIDIS J C,MACLEAN J J,ROUGHLEY P J,et al.Effects of mechanical loading on intervertebral disc metabolism in vivo[J].J Bone Joint Surg Am,2006,88 Suppl 2(1):41-46.
[8] XIA D D,LIN S L,WANG X Y,et al.Effects of shear force on intervertebral disc:an in vivo rabbit study[J].Eur Spine J,2015,24(8):1711-1719.
[9] KROEBER M W,UNGLAUB F,WANG H,et al.New in vivo animal model to create intervertebral disc degeneration and to investigate the effects of therapeutic strategies to stimulate disc regeneration[J].Spine,2002,27(23):2684-2690.
[10] KROEBER M,UNGLAUB F,GUEHRING T,et al.Effects of controlled dynamic disc distraction on degenerated intervertebral discs:an in vivo study on the rabbit lumbar spine model[J].Spine,2005,30(2):181-187.
[11] HUANG G F,ZOU J,SHI J,et al.Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration[J].Evidence-Based Complementary Altern Med,2015,2015:386012.
[12] 许斌,陈跃先,赵建宁,等.腰椎后外侧融合动物模型及邻近节段的病理变化[J].医学研究生学报,2009,22(3):249-251.
[13] 吕存贤,吴永琴.异常应力负荷及椎间失稳建立实验性兔腰椎间盘退变模型[J].浙江中西医结合杂志,2011,21(3):161-162.
[14] KEPLER C K,ANDERSON D G,TANNOURY C,et al.Intervertebral disk degeneration and emerging biologic treatments[J].J Am Acad Orthop Surg,2011,19(9):543-553.
[15] MASUDA K,AOTA Y,MUEHLEMAN C,et al.A novel rabbit model of mild,reproducible disc degeneration by an anulus needle puncture:correlation between the degree of disc injury and radiological and histological appearances of disc degeneration[J].Spine,2005,30(1):5-14.
[16] 蒋新华,张伶,陈建宇,等.透视引导下穿刺构建兔椎间盘退变模型的影像和病理变化[J].中国组织工程研究与临床康复,2011,15(48):8931-8934.
[17] KIM D W,CHUN H J,LEE S K.Percutaneous needle puncture technique to create a rabbit model of traumatic degenerative disc disease[J].World Neurosurg,2015,84(2):438-445.
[18] 崔运能,周荣平,麦奇光,等.肌间隙入路腰椎间盘退变模型的构建[J].南方医科大学学报,2012,32(3):404-408.
[19] MOSS I L,ZHANG Y,SHI P,et al.Retroperitoneal approach to the intervertebral disc for the annular puncture model of intervertebral disc degeneration in the rabbit[J].Spine J,2013,13(3):229-234.
[20] HOU C,TAN G,ZHUANG W,et al.Establishment of a new animal model for ischemic lumbar vertebrae[J].Int J Clin Exp Med,2014,8(7):10646-10656.
[21] 贺庆,李兵,卓祥龙,等.经皮纤维环穿刺与经肌间隙纤维环刀刺建立兔椎间盘退变模型[J].中国组织工程研究,2014(13):2059-2064.
[22] SOBAJIMA S,KOMPEL J F,KIM J S,et al.A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI,X-ray,and histology[J].Spine,2005,30(1):15-24.
[23] 吕浩然,杨进顺,黄文铎,等.终板损伤建立兔腰椎间盘退变模型[J].广东医学,2008,29(1):44-45.
[24] 徐涛涛,廖菲,金红婷,等.椎间盘退变与细胞死亡的相关研究进展[J].中国骨伤,2015,28(7):673-678.
[25] COLLIOU O.Role of mechanical loading in intervertebral disc degeneration[M].San Franciso:PhD diss,University of California,1998:1-124.
[26] 白亦光,韩小伟,张旭乾,等.穿刺抽吸法诱导兔椎间盘退变模型[J].川北医学院学报,2013,28(2):91-94.
[27] 邵辉,卞正君,孙建华.纤维环穿刺髓核抽吸法建立兔椎间盘退变模型[J].石河子大学学报:自然科学版,2015,33(1):97-101.
[28] HOOGENDOORN R J,HELDER M N,KROEZE R J,et al.Reproducible long-term disc degeneration in a large animal model[J].Spine,2008,33(9):949-954.
[29] NORDBY E J,JAVID M J.Continuing experience with chemonucleolysis[J].Mt Sinai J Med,2000,67(4):311-313.
[30] GULLBRAND S E,ASHINSKY B G,MARTIN J T,et al.Correlations between quantitative T2 and T1ρ MRI,mechanical properties and biochemical composition in a rabbit lumbar intervertebral disc degeneration model[J].J Orthop Res,2016, 34(8):1382-1388.
[31] YAMAGATA T,SAITO H,HABUCHI O,et al.Purification and properties of bacterial chondroitinases and chondrosulfatases[J].J Biol Chem,1968,243(7):1523-1535.
[32] IMAI Y,OKUMA M,AN H S,et al.Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC[J].Spine,2007,32(11):1197-1205.
[33] JR O T,JOHNSON S L,AGUIAR D J,et al.Fibronectin and its fragments increase with degeneration in the human intervertebral disc[J].Spine,2000,25(21):2742-2747.
[34] 王娜,吴成爱,赵丹慧,等.应用纤连蛋白片段建立椎间盘退变动物模型[J].中国脊柱脊髓杂志,2013,23(1):47-53.
[35] LIU H F,ZHANG H,QIAO G X,et al.A novel rabbit disc degeneration model induced by fibronectin fragment[J].Joint Bone Spine,2013,51(4):301-306.
[36] KIM K S,YOON S T,LI J,et al.Disc degeneration in the rabbit:a biochemical and radiological comparison between four disc injury models[J].Spine,2005,30(1):33-37.
[37] WANG H,LIU H,ZHENG Z M,et al.Role of death receptor,mitochondrial and endoplasmic reticulum pathways in different stages of degenerative human lumbar disc[J].Apoptosis,2011,16(10):990-1003.
[38] BACHMEIER B E,LANCU C M,JOCHUM M,et al.Matrix metalloproteinases in cancer:comparison of known and novel aspects of their inhibition as a therapeutic approach[J].Expert Rev Anti-Infect Ther,2005,5(5):149-163.
[39] 毛波,刘少喻,李德平,等.基于晚期糖基化终末产物与腰椎间盘突出症临床发病之间关系的多因素Logistic分析[J].现代医学,2013,41(6):375-379.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 412154 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364