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肾透明细胞癌与表观遗传学
作者:郭倚天1  陈明2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学 附属中大医院, 江苏 南京 210009
关键词:DNA甲基化 组蛋白修饰 非编码RNA 肾透明细胞癌 综述 
分类号:R737.11
出版年·卷·期(页码):2017·36·第四期(651-656)
摘要:

肾透明细胞癌是常见的具有基因及表观遗传学变异的泌尿系统恶性肿瘤。本文作者综述了肾透明细胞癌表观遗传学特征包括DNA甲基化、组蛋白修饰、微小RNA和最近发现的长链非编码RNA的研究成果。这些表观遗传学特点可以用于肾透明细胞癌的早期诊断、患者预后评估及靶向治疗。随着高通量测序的广泛应用,肾透明细胞癌的表观遗传学变化可以获得更精准的确定,并为其研究与治疗提供新的导向。

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