>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
2型糖尿病患者认知功能磁共振研究的最新进展
作者:祁纳1  崔莹2  滕皋军2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 江苏省分子影像与功能影像重点实验室/东南大学附属中大医院 放射科, 江苏 南京 210009
关键词:2型糖尿病 认知功能 磁共振研究 综述 
分类号:R587.1
出版年·卷·期(页码):2017·36·第四期(641-645)
摘要:

认知功能受损在2型糖尿病(T2DM)患者中并不罕见,具体机制尚未明确,其检测主要依靠认知功能量表测试。磁共振成像可从大脑结构、代谢及功能等方面为2型糖尿病患者认知功能改变机制提供信息。本文作者主要对近年来T2DM患者认知功能磁共振最新研究进行综述。

参考文献:

[1] KRUG E G.Trends in diabetes:sounding the alarm[J].Lancet,2016,387(10027):1485-1486.
[2] SAEDI E,GHEINI M R,FAIZ F,et al.Diabetes mellitus and cognitive impairments[J].World J Diabetes,2016,7(17):412-422.
[3] RESKE-NIELSEN E,LUNDBAEK K,RAFAELSEN O J.Pathological changes in the central and peripheral nervous system of young long-term diabetics:I.Diabetic encephalopathy[J].Diabetologia,1966,1(3-4):233-241.
[4] ZILLIOX L A,CHADRASEKARAN K,KWAN J Y,et al.Diabetes and cognitive impairment[J].Curr Diab Rep,2016,16(9):87.
[5] 闫赋琴,孙小萌,徐春.尼莫地平联合叶酸及维生素B12对老年2型糖尿病合并轻度认知功能障碍患者的干预研究[J].现代医学,2016,44(3):319-324.
[6] 王芳,赵衡,唐德秋.2型糖尿病与认知障碍相关性磁共振研究现状及进展[J].医学综述,2016,22(16):3202-3206.
[7] 刘文,刘晟,王维,等.对2型糖尿病患者相关脑损害的MRI研究进展[J].磁共振成像,2015(10):787-791.
[8] LI W,RISACHER S L,HUANG E,et al.Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort[J].Neurology,2016,87(6):595-600.
[9] HUGENSCHMIDT C E,LOVATO J F,AMBROSIUS W T,et al.The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain MRI findings:the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial[J].Diabetes Care,2014,37(12):3244-3252.
[10] MEHTA D,PIMENTEL D A,NUNEZ M Z,et al.Subclinical albuminuria is linked to gray matter atrophy in type 2 diabetes mellitus[J].Metabolism,2014,63(11):1390-1397.
[11] BRUNDEL M,KAPPELLE L J,BIESSELS G J.Brain imaging in type 2 diabetes[J].Eur Neuropsychopharmacol,2014,24(12):1967-1981.
[12] REIJMER Y D,van den BERG E,de BRESSER J,et al.Accelerated cognitive decline in patients with type 2 diabetes:MRI correlates and risk factors[J].Diabetes Metab Res Rev,2011,27(2):195-202.
[13] CLIMIE R E,MORAN C,CALLISAYA M,et al.Abdominal obesity and brain atrophy in type 2 diabetes mellitus[J].PLoS One,2015,10(11):e142589.
[14] HSU F C,YUAN M,BOWDEN D W,et al.Adiposity is inversely associated with hippocampal volume in African Americans and European Americans with diabetes[J].J Diabetes Complications,2016,30(8):1506-1512.
[15] HEMPEL R,ONOPA R,CONVIT A.Type 2 diabetes affects hippocampus volume differentially in men and women[J].Diabetes Metab Res Rev,2012,28(1):76-83.
[16] WISSE L E,de BRESSER J,GEERLINGS M I,et al.Global brain atrophy but not hippocampal atrophy is related to type 2 diabetes[J].J Neurol Sci,2014,344(1-2):32-36.
[17] ROBERTS R O,KNOPMAN D S,PRZYBELSKI S A,et al.Association of type 2 diabetes with brain atrophy and cognitive impairment[J].Neurology,2014,82(13):1132-1141.
[18] 周飞,刘任远,王慧婷,等.轻度认知障碍和阿尔茨海默病患者扣带回~1H-MRS的对照研究[J].东南大学学报:医学版,2015,34(5):775-779.
[19] 陆雪芳.2型糖尿病脑损伤患者双侧海马1H-MRS代谢物与认知功能的相关性研究[D].大连:大连医科大学,2015.
[20] 马晓臣,王桂芝,王元春,等.2型糖尿病患者脑海马区氢质子波谱的临床分析[J].现代中西医结合杂志,2010(10):1174-1175.
[21] SINHA S,EKKA M,SHARMA U,et al.Assessment of changes in brain metabolites in Indian patients with type-2 diabetes mellitus using proton magnetic resonance spectroscopy[J].BMC Res Notes,2014,7:41.
[22] LIN Y,ZHOU J,SHA L,et al.Metabolite differences in the lenticular nucleus in type 2 diabetes mellitus shown by proton MR spectroscopy[J].AJNR Am J Neuroradiol,2013,34(9):1692-1696.
[23] THOMPSON P M,HAYASHI K M,DUTTON R A,et al.Tracking Alzheimer's disease[J].Ann N Y Acad Sci,2007,1097:183-214.
[24] 杨雯,卢春强,居胜红.慢性额叶挫裂伤患者脑白质结构异常的影像学证据[J].现代医学,2016,44(7):944-948.
[25] 黄文盛,周红.磁共振弥散张量成像技术在脑白质病变与认知功能障碍关系研究中的作用[J].东南大学学报:医学版,2013(4):522-525.
[26] YAU P L,JAVIER D,TSUI W,et al.Emotional and neutral declarative memory impairments and associated white matter microstructural abnormalities in adults with type 2 diabetes[J].Psychiatry Res,2009,174(3):223-230.
[27] XIE Y,ZHANG Y,QIN W,et al.White matter microstructural abnormalities in type 2 diabetes mellitus:a diffusional kurtosis imaging snalysis[J].AJNR Am J Neuroradiol,2017,38(3):617-625.
[28] ZHANG J,WANG Y,WANG J,et al.White matter integrity disruptions associated with cognitive impairments in type 2 diabetic patients[J].Diabetes,2014,63(11):3596-3605.
[29] BULLMORE E T,BASSETT D S.Brain graphs:graphical models of the human brain connectome[J].Annu Rev Clin Psychol,2011,7:113-140.
[30] REIJMER Y D,LEEMANS A,BRUNDEL M,et al.Disruption of the cerebral white matter network is related to slowing of information processing speed in patients with type 2 diabetes[J].Diabetes,2013,62(6):2112-2115.
[31] ZHANG J H,XU H Z,SHEN Q F,et al.Nepsilon-(carboxymethyl)-lysine,white matter,and cognitive function in diabetes patients[J].Can J Neurol Sci,2016,43(4):518-522.
[32] van BUSSEL F C,BACKES W H,HOFMAN P A,et al.Altered hippocampal white matter connectivity in type 2 diabetes mellitus and memory decrements[J].J Neuroendocrinol,2016,28(3):12366.
[33] HSU J L,CHEN Y L,LEU J G,et al.Microstructural white matter abnormalities in type 2 diabetes mellitus:a diffusion tensor imaging study[J].Neuroimage,2012,59(2):1098-1105.
[34] FANG P,AN J,TAN X,et al.Changes in the cerebellar and cerebro-cerebellar circuit in type 2 diabetes[J].Brain Res Bull,2017,130:95-100.
[35] BUCKNER R L,ANDREWS-HANNA J R,SCHACTER D L.The brain's default network:anatomy,function,and relevance to disease[J].Ann N Y Acad Sci,2008,1124:1-38.
[36] ZHOU H,LU W,SHI Y,et al.Impairments in cognition and resting-state connectivity of the hippocampus in elderly subjects with type 2 diabetes[J].Neurosci Lett,2010,473(1):5-10.
[37] WANG Y F,JI X M,LU G M,et al.Resting-state functional MR imaging shed insights into the brain of diabetes[J].Metab Brain Dis,2016,31(5):993-1002.
[38] FOX M D,RAICHLE M E.Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging[J].Nat Rev Neurosci,2007,8(9):700-711.
[39] LOGOTHETIS N K,PAULS J,AUGATH M,et al.Neurophysiological investigation of the basis of the fMRI signal[J].Nature,2001,412(6843):150-157.
[40] ZANG Y,JIANG T,LU Y,et al.Regional homogeneity approach to fMRI data analysis[J].Neuroimage,2004,22(1):394-400.
[41] WANG C X,FU K L,LIU H J,et al.Spontaneous brain activity in type 2 diabetics revealed by amplitude of low-frequency fluctuations and its association with diabetic vascular disease:a resting-state FMRI study[J].PLoS One,2014,9(10):e108883.
[42] PENG J,QU H,PENG J,et al.Abnormal spontaneous brain activity in type 2 diabetes with and without microangiopathy revealed by regional homogeneity[J].Eur J Radiol,2016,85(3):607-615.
[43] CUI Y,JIAO Y,CHEN Y C,et al.Altered spontaneous brain activity in type 2 diabetes:a resting-state functional MRI study[J].Diabetes,2014,63(2):749-760.
[44] MUSEN G,JACOBSON A M,BOLO N R,et al.Resting-state brain functional connectivity is altered in type 2 diabetes[J].Diabetes,2012,61(9):2375-2379.
[45] CUI Y,JIAO Y,CHEN H J,et al.Aberrant functional connectivity of default-mode network in type 2 diabetes patients[J].Eur Radiol,2015,25(11):3238-3246.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 409405 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364