Objective:To evaluate the predictive value of sustained inflation on fluid responsiveness in patients of acute respiratory distress syndrome (ARDS) with mechanical ventilation. Methods:The study was conducted in ICU of Danyang People's Hospital from March to December in 2016. During this period, ARDS patients with mechanical ventilation were enrolled. We measured the changes in cardiac index (CI) induced by fluid challenge after 15 minutes. Fluid responsiveness was defined by a fluid challenge-induced increase in CI greater than or equal to 10%. According to this, patients were divided into two groups-responders (FR) and non-responders (NFR). Logistics analysis was performed to find out the indicators that can predict the responsiveness during SI and then ROC analysis was performed to evaluate the diagnostic value of the indicators. Results:40 patients were enrolled in the study, 22 in the FR group and 18 in the NFR group. Compared with SI, there were significant differences of CI (2.90±0.24 vs 2.61±0.24) (P<0.05) and systolic blood pressure (SBP)[(102.4±8.0)mmHg vs 94.0±8.6)mmHg] in FR group. CI and SBP during SI (SI-△CI and SI-△SBP) could predict fluid responsiveness, the AUC of SI-△CI and SI-△SBP was 0.934 and 0.851 respectively with the sensitivity of 90.9% and 90.9% and specificity of 88.9% and 77.8%, respectively. Conclusion:SI-△CI, SI-△SBP can predict fluid responsiveness of patients in ARDS with mechanical ventilation. |
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