Objective:To study the effect of Huaier Granule on immune function and quality of life in patients with breast cancer after operation and chemotherapy. Methods:A total of 90 patients were confirmed by pathology examination after operation for breast cancer, and were randomly divided into two groups:treatment group receiving chemotherapy of FEC scheme (0.6 g·m-2 cyclophosphamide, intravenous injection, d1; 100 mg·m-2 epirubicin, intravenous drip, d1; 0.6 g·m-2 5-fluorouracil, intravenous drip, dl), and oral Huaier Granule (20 g each time, 3 times·d-1, 21 days for a cycle), control group was only given chemotherapy of FEC scheme. Peripheral NK cells, CD3+, CD4+, and CD4+/CD8+ ratio were determined before and after the chemotherapy. The quality of life, clinical efficacy and immune function were compared between the two groups after 2 cycles. Results:There were no statistically significant differences (P>0.05) between the treatment group and the control group in peripheral NK cells, CD3+,CD4+,and CD4+/CD8+ ratio. After the treatment for 2 weeks, NK cells, CD3+, CD4+ and CD4+/CD8+ ratio of the patients were higher in the treatment group than those of the control group (P<0.05). In terms of improving TCM symptom and the quality of life scores, the treatment group was significantly better than the control group, with a significant difference (P<0.05). Conclusion:Huaier Granule can enhance the immunity, improve the clinical efficacy and quality of life of the breast cancer patients with postoperative chemotherapy. Therefore, it is worthy of further clinical research. |
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