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中老年人四肢血管僵硬度与骨质疏松的相关性分析
作者:周婉婉  梁冰 
单位:蚌埠医学院第一附属医院 老年病科, 安徽 蚌埠 233003
关键词:骨密度 臂-踝脉搏波传导速度 动脉硬化 骨质疏松 
分类号:R543.5;R444
出版年·卷·期(页码):2017·36·第三期(434-438)
摘要:

目的:探讨中老年人四肢血管僵硬度与骨质疏松的相关性。方法:收集91例住院患者,完善四肢多普勒超声、骨密度及相关生化指标。根据骨密度T值将患者分为骨量正常组、骨量减少组、骨质疏松组3组,比较3组的相关检验指标;以臂-踝脉搏波传导速度(baPWV)值将患者分为低baPWV组和高baPWV组,分析两组的临床因素及生化指标。结果:(1)骨量正常组、骨量减少组及骨质疏松组之间性别、年龄、baPWV及体质指数(BMI)差异有统计学意义(P<0.05);空腹血糖(FBG)、胆固醇(CHO)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、收缩压(SBP)、舒张压(DBP)在3组之间差异无统计学意义(P>0.05)。(2)低baPWV组与高baPWV组之间性别、年龄、BMI、SBP及骨密度差异有统计学意义(P<0.05);FBG、CHO、TG、HDL、LDL、DBP在两组间差异无统计学意义(P>0.05)。(3) baPWV与年龄、SBP呈正相关,与骨密度T值、BMI呈负相关;骨密度T值与年龄、baPWV呈负相关,与BMI呈正相关。(4)年龄、SBP是中老年人血管僵硬的危险因素,骨密度T值、BMI是中老年人血管僵硬的保护因素。同时年龄和baPWV是老年男性人群骨质疏松症的危险因素,BMI是老年男性人群骨质疏松症的保护因素。结论:中老年人动脉硬化和骨质疏松具有相关性,外周动脉硬化及骨密度的早期检测有利于减少心血管事件及骨质疏松的发生。

Objective:To discuss the correlation between limb arterial stiffness and osteoporosis in middle-aged and elderly people. Methods:Ninety-one hospitalized patients were included in this study, and their bone mineral density and brachial-ankle pulse wave velocity(baPWV)were measured by dual energy X-ray bone density and Doppler ultrasonography. According to bone mineral density T value, the patients were divided into normal bone mass, osteopenia and osteoporosis group. Meanwhile, the patients were divided into low baPWV and high baPWV group in accordance with baPWV value, and the clinical characteristics and biochemical indexes of the groups were compared and analyzed. Results:(1)The age, baPWV and BMI had significant differences in the different bone mass groups(P<0.05).No significant differences were found in the levels of FBG,CHO,TG,HDL,LDL,SBP and DBP in the three groups(P>0.05).(2)There were significant differences of the age, BMI, SBP and T value(P<0.05)between the low baPWV and the high baPWV group,while there were no statistical differences in the levels of FBG, CHO, TG, HDL, LDL, SBP and DBP between the two groups(P>0.05).(3)baPWV was positively correlated with age and SBP,but negatively correlated with bone mineral density T value and BMI. Bone mineral density T value was negatively correlated with age and baPWV, but positively correlated with BMI. Conclusion:Limb arterial stiffness is related with osteoporosis in middle-aged and elderly people. Early detection of peripheral arterial sclerosis and bone density may be helpful for the prevention of atherosclerosis and osteoporosis.

参考文献:

[1] YE C Y,XU M Y,WAGN S D,et al.Decreased bone mineral density is an independent predictor for the development of atherosclerosis:A systematic review and meta-analysis[J].PLoS One,2016,11(5):1-18.
[2] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊治指南(2011版)[J].中华骨质疏松和骨矿盐疾病杂志,2011,4(1):2-17.
[3] 宋美香,周晓辉.老年男性骨质疏松与动脉硬化相关性研究[D].乌鲁木齐:新疆医科大学,2013:1-20.
[4] ISSEVER A S,KENTENICH M,KÖHLITZ T,et al.Osteoporosis and atherosclerosis:a post-mortem MDCT study of an elderly cohort[J].Eur Radiol,2013,23:2823-2829.
[5] BANDEIRA E,NEVES A P,COSTA C,et al.Association between vascular calcification and osteoporosis in men with type 2 diabetes[J].J Clin Densitom,2012,15(1):55-60.
[6] KIM S N,LEE H S,NAM H S,et al.Carotid intima-media thickness is inversely related to bone density in female but not in male patients with acute stroke[J].J Neuroimaging,2016,26(1):83-88.
[7] KANG K.Low bone mineral density is associated with intracranial posterior circulation atherosclerosis in women[J].Bone,2015,81:669-674.
[8] GRIFFITH J F,KUMTA S M,HUANG Y.Hard arteries,weak bones[J].Skeletal Radiol,2011,40:517-521.
[9] TOWLER D A.Arteriosclerosis,bone biology,and calciotropic hormone signaling:learning the ABCs of disease in the bone-vascular axis[J].J Am Soc Nephrol,2014,26:1-3.
[10] MOHAMMADI A,SHATERI K,BEHZADI F,et al.Relationship between intima-media thickness and bone mineral density in postmenopausal women:a cross-sectional study[J].Int J Clin Exp Med,2014,7(12):5535-5540.
[11] SANDRA M,ZORIN M,ROBERT S,et al.Osteoprotegerin and vascular calcification:clinical and prognostic relevance[J].Coll Antropol,2015,39(2):461-468.
[12] OBANDO N C,KAVOUSI M,LENNEP J R V,et al.Bone health and coronary artery calcification:The rotterdam study[J].Atherosclerosis,2015,241:278-283.
[13] SEO S K,YUN B H,NOE E B,et al.Decreased bone mineral density is associated with coronary atherosclerosis in healthy postmenopausal women[J].Arch Gynecol Obste,2015,58(2):144-149.
[14] LEWIS J R,SCHOUSBOE J T,LIM W H,et al.Abdominal aortic calcification identified on lateral spine images from bone densitometers are a marker of generalized atherosclerosis in elderly women[J].Arterioscler Thromb Vasc Biol,2016,36:166-173.
[15] 包勤文,申潇竹.老年人骨密度测定在颈动脉硬化随访观察中的意义[J].中国骨质疏松杂志,2014,20(2):175-177.

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