辅酶Q10联合卡托普利对急性一氧化碳中毒后心肌损伤的治疗效果-东南大学学报医学版

辅酶Q10联合卡托普利对急性一氧化碳中毒后心肌损伤的治疗效果

单位：1. 唐山市工人医院超声科, 河北唐山 063000;
2. 唐山市工人医院老年病科, 河北唐山 063000

分类号：R595.1

出版年·卷·期（页码）：2017·36·第三期（429-433）

摘要：

目的：探讨急性一氧化碳（CO）中毒后心脏损伤及其临床治疗方案。方法：收集我院收治的200例急性CO中毒后出现心脏损伤患者，按照随机对照原则分为卡托普利常规治疗的对照组和在常规治疗基础上加用辅酶Q10胶囊的实验组各100例；疗程12周，两组患者治疗6、12周后复查超声心动图与心电图、超敏C反应蛋白（hs-CRP）、脑钠肽（pro-BNP）、肌酸激酶同工酶（CK-MB）、肌钙蛋白（cTnI）等水平。结果：治疗6周后，实验组患者的CK-MB水平明显低于对照组（P=0.002）；治疗12周后，实验组LVEDD、LVESD较对照组明显降低，而LVEF明显增高（P=0.001）；治疗12周后，实验组pro-BNP、cTnI及CRP水平明显低于对照组（P=0.001、0.002、0.001）。结论：对急性CO中毒后心肌损伤患者，联合使用辅酶Q10胶囊与卡托普利可以有效抑制心脏恶性重塑，抑制缺氧引起的心肌损害，改善左心室收缩功能。

Objective:To evaluate the effect of captopril combined with coenzyme Q10 on cardiac injury after acute carbon monoxide poisoning. Methods:Two hundred patients of cardiac injury after acute CO poisoning were enrolled in this study. All the patients were randomly and equally divided into control group treated with captopril and experimental group treated with captopril combined coenzyme Q10. The course of treatment was 12 weeks. After treatment for 6 and 12 weeks, echocardiography was conducted on all the patients and the levels of high sensitive C reactive protein(hs-CRP), pro-brain natriuretic peptide(pro-BNP), CK-MB(cTnI)and cardiac troponin I were determined. Results:After 6 weeks'treatment, CK-MB levels of the experimental group were significantly lower than those of the control group(P=0.002). After 12 weeks of treatment, the levels of LVEDd and LVESD in experimental group were significantly lower than those in the control group, while that of LVEF was significantly higher(P=0.001). The pro-BNP, cTnI and CRP levels in the experimental group was significantly lower than those of the control group(P=0.001, 0.002, 0.001)after 12 weeks of treatment. Conclusion:Combined use of captopril and coenzyme Q10 capsules can effectively inhibit the malignant remodeling of the heart and hypoxia-induced myocardial damage, and improve the left ventricular systolic function in patients with myocardial injury caused by acute CO poisoning.

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