Objective:To study the effect of GnRH-a and oral contraceptive assisted laparoscopic surgery on subjective symptom scores and sex hormone levels in patients with severe endometriosis. Methods:Seventy-six patients with severe endometriosis confirmed by laparoscopy were divided into oral contraceptive group and GnRH-a group using a random number table method with 38 in each group. After the operation, patients in GnRH-a group were treated with subcutaneous injection of GnRH-a, and patients in contraceptive oral group took desogestrel and ethinylestradiol tablets orally. The subjective symptom score, sex hormone level, pregnancy rate, recurrence rate and adverse reactions were compared between the two groups. Results:Three months after operation, the levels of E₂, FSH and LH were significantly decreased in the two groups, the levels of which in GnRH-a group were lower than those in contraceptive group(P<0.05). After 3 months, the pelvic symptoms, physical signs and total subjective symptom scores decreased significantly, which were lower in GnRH-a group than those in oral contraceptive group(P<0.05). Fifteen months after operation, the recurrence rate of group GnRH-a was lower than that of oral contraceptive group(P<0.05). There was no significant difference in pregnancy rates between the two groups(P>0.05). The incidence of adverse reactions in the oral contraceptive group was lower than that in GnRH-a group(P<0.05). After the withdrawal of the treatment, the symptoms disappeared gradually,and 4 months after operation, all the patients in the two groups returned to a regular menstrual cycle. Conclusion:GnRH-a assisted laparoscopic surgery in the treatment of severe endometriosis is better than oral contraceptive assisted laparoscopic surgery. It can significantly reduce the level of sex hormones, subjective symptom score and recurrence rate, which is worthy of clinical application.