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HMGB1及其在自身免疫性疾病中的作用
作者:李静  胡艳  王丽红  徐前飞  刘亚蒙  葛健 
单位:安徽医科大学第一附属医院 血液内科, 安徽 合肥 230022
关键词:高迁移率族蛋白1 自身免疫性疾病 过敏性紫癜 类风湿性关节炎 综述 
分类号:R593.2
出版年·卷·期(页码):2017·36·第二期(294-297)
摘要:

高迁移率族蛋白B1(HMGB1)是一种广泛表达在真核细胞内的非组蛋白核蛋白。正常情况下,HMGB1主要位于细胞核,可与DNA结合,参与DNA复制、重组、转录和修复。此外,细胞受刺激、损伤或死亡后可释放HMGB1到细胞外与多种细胞表面抗体结合,参与多种自身免疫性疾病的病理生理过程。作者就HMGB1生物学特性及其在自身免疫性疾病中的研究进展作一综述。

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