急性肾损伤是临床常见的危重症，发病率和死亡率高。由于急性肾损伤具有潜在可逆性，因此提高早期诊断水平对患者预后有重要影响。利用超声造影技术，结合时间-强度曲线各参数，定量分析及评估肾脏血流灌注情况，从而反映肾脏损伤程度及病程进展。

[1] NASH K,HAFEEZ A,HOU S.Hospital-acquired renal insufficiency[J].Am J Kidney Dis,2002,39(5):930-936.
[2] YMPA Y P,SAKR Y,REINHART K,et al.Has mortality from acute renal failure decreased? A systematic review of the literature[J].Am J Med,2005,118(8):827-832.
[3] MEHTA R L,KELLUM J A,SHAH S V,et al.Acute Kidney Injury Network:report of an initiative to improve outcomes in acute kidney injury[J].Crit Care,2007,11(2):R31.
[4] RAHMAN M,SHAD F,SMITH M C.Acute kidney injury:a guide to diagnosis and management[J].Am Fam Physician,2012,86(7):631-639.
[5] LEWINGTON A,KANAGASUNDARAM S.Renal Association Clinical Practice Guidelines on acute kidney[J].Nephron Clin Pract,2011,118(Suppl 1):c349-c390.
[6] ILIESCU R,FERNANDEZ S R,KELSEN S,et al.Role of renal microcirculation in experimental renaovascular disease[J].Nephrol Dial Transplant,2005,25(4):1079-1087.
[7] MILOVANCEVA-POPOVSKA M,DZIKOVA S.Doppler ultrasonography:a tool for nephrologists--single centre experience[J].Prilozi,2008,29(1):107-128.
[8] KELLUM A J,LAMEIRE N.Diagnosis,evaluation,and management of acute kidney injury:a KDIGO summary (Part 1)[J].Crit Care,2013,17 (1):204.
[9] 张惠,陈琴,岳林先,等.超声造影及其定量分析对睾丸肿块的诊断价值[J].现代医学,2016,44(9):1224-1228.
[10] GOCZE I,WOHLGEMUTH W A,SCHLITT H J,et al.Contrast-enhanced ultrasonography for bedside imaging in subclinical acute kidney injury[J].Intensive Care Med,2014,40(3):431.
[11] MCARTHUR C,BAXTER G M.Current and potential renal applications of contrast-enhanced ultrasound[J].Clinical Radiology,2012,67(9):909-922.
[12] PEYMAN S A,McLAUGHLAN J R,ABOU-SALEH R H,et al.On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging[J].Lab Chip,2016,16(4):679-687.
[13] 杨荣,李明星.窒息新生儿肾血流动力学改变与血清胱抑素 C 的相关性研究[J].中国现代医药杂志,2011,13(5):66-68.
[14] SCHNEIDER A G,HOFMANN L,WUERZNER G,et al.Renal perfusion evaluation with contrast enhanced ultrasonography[J].Nephrol Dial Transplant,2012,27(2):674-681.
[15] PINTO F,VALENTINO M,ROMANINI L,et al.The role of CEUS in the assessment of haemodynamically stable patients with blunt abdominal trauma[J].Radiol Med,2015,120(1):3-11.
[16] CAGINI L,GRAVANTE S,MALASPINA C M,et al.Contrast enhanced ultrasound (CEUS) in blunt abdominal trauma[J].Critical Ultrasound Journal,2013,5(1):S9.
[17] 袁桂忠,李叶阔,王莎莎,等.超声造影诊断兔闭合性肾外伤肾动脉闭塞的价值[J].中国超声医学杂志,2013,29(10):942-944.
[18] XU R X,LI Y K,LI T,et al.Real-time 3-dimensional contrast-enhanced ultrasound in detecting hemorrhage of blunt renal trauma[J].American Journal of Emergency Medicine,2013,31(10):1427-1431.
[19] HIGGINS R,ZEHNDER D,CHEN K,et al.The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation[J].Nephrol Dial Transplant,2010,25(4):1306-1312.
[20] GRZELAK P,SZYMCZYK K,STRZELCZYK J,et al.Perfusion of kidney graft pyramids and cortex in contrast-enhanced ultrasonography in the determination of the cause of delayed graft function[J].Ann Transplant,2011,16(1):48-53.
[21] BENOZZI L,CAPPELLI G,GRANITO M,et al.Contrast-enhanced sonography in early kidney graft dysfunction[J].Transplantation Proceedings,2009,41(4):1214-1215.
[22] GRZELAK P,KURNATOWSKA I,SAPIEHA M,et al.Disturbances of kidney graft perfusion as indicators of acute renal vein thrombosis in contrast-enhanced ultrasonography[J].Transplantation Proceedings,2011,43(8):3018-3020.
[23] JIN Y,YANG C,WU S,et al.A novel simple noninvasive in-dex to predict renal transplant acute rejection by contrast-enhanced ultrasonography[J].Transplantation,2015,99(3):636-641.
[24] MARISCALCO G,COTTINI M,DOMINICI C,et al.The effect of timing of cardiac catheterization on acute kidney injury after cardiac surgery is influenced by the type of operation[J].Int J Cardiol,2014,173(1):46-54.
[25] KUMAR A B,SUNEJIA M.Cardiopulmonary bypass-associated acute kidney injury[J].Anesthesiology,2011,114(4):964-970.
[26] SCHNEIDER A G,GOODWIN M D,SCHELLEMAN A,et al.Contrast-enhanced ultrasound to evaluate changes in renal cortical perfusion around cardiac surgery:a pilot study[J].Crit Care,2013,17(4):R138.
[27] 钟晓绯,朱达,卢强,等.超声造影监测儿童及婴幼儿体外循环下肾脏微循环灌注的初探[J].四川大学学报:医学版,2013,44(4):646-650.
[28] RAO A R,GRAY R,MAYER E,et al.Occlusion angiography using intraoperative contrast-enhanced ultrasound scan (CEUS):a novel technique demonstrating segmental renal blood supply to assist zero-ischaemia robot-assisted partial nephrectomy[J].Eur Urol,2013,63(5):913-919.
[29] ALENEZI A N,KARIM O.Role of intra-operative contrast-enhanced ultrasound (CEUS) in robotic-assisted nephron-sparing surgery[J].J Robot Surg,2015,9(1):1-10.
[30] 刘海芳,冯一星,勇强,等.超声造影定量评价肾动脉狭窄支架置入术前术后实质血流灌注的研究[J].中国超声医学杂志,2014,30(10):908-910.
[31] CHEN H,WANG L,XING B Z,et al.Ischemic postconditioning attenuates inflammation in rats following renal ischemia and reperfusion injury[J].Exp Ther Med,2015,10(2):513-518.
[32] GE Y Z,WU R,XIN H,et al.Effects of ischemic preconditioning on the systemic and renal hemodynamic changes in renal ischemia reperfusion injury[J].Int J Clin Exp Pathol,2015,8(2):1128-1140.
[33] 叶帆,李明星,罗志建,等.超声造影监测缺血再灌注损伤兔肾皮质血流动力学改变的实验研究[J].中国临床医学影像杂志,2015,26(6):413-416.
[34] LI M,LUO Z,CHEN X,et al.Use of contrast-enhanced ultrasound to monitor rabbit renal ischemia-reperfusion injury and correlations between time-intensity curve parameters and renal ICAM-1 expression[J].Clin Hemorheol Microcirc,2015,59(2):123-131.