>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
胰高血糖素样多肽-¹在²型糖尿病治疗中的新进展
作者:许晓娜  乔虹 
单位:哈尔滨医科大学第二附属医院 内分泌代谢病科五病区, 黑龙江 哈尔滨 150086
关键词:胰高血糖素样多肽-1 2型糖尿病 胰岛素抵抗 L细胞 肠促胰素 综述 
分类号:R587.1
出版年·卷·期(页码):2017·36·第二期(270-274)
摘要:

胰高血糖素样多肽(GLP-¹)是由进食刺激肠道L细胞分泌的肠促胰素,通过与GLP-¹R结合发挥胰腺内和胰腺外两方面的功能。在人体,GLP-¹R广泛分布在肠道、中枢神经系统、肺脏、肾脏、垂体、心脏及血管内皮等部位。越来越多的研究发现,GLP-¹除了有促胰岛素分泌、抑制胰高血糖素分泌、促进胰岛β细胞增生且抑制其凋亡等胰腺内作用外,还表现出许多令人欣喜的胰腺外功能,如:抑制胃排空、增加饱腹感、增加外周组织对胰岛素的敏感性及心血管、神经系统等保护作用。基于GLP-¹独特的胰腺内和胰腺外生理功能,在²型糖尿病(Þ²ÐM)的病理生理中GLP-¹成为重要的阻止疾病进展的保护性因素。近年来研究者一直试图拓展以GLP-¹为靶点的治疗策略在Þ²ÐM中的应用。因此,作者对GLP-¹在Þ²ÐM病理生理中的作用、相关分子作用机制的研究新进展以及GLP-¹在Þ²ÐM治疗方面的新突破进行综述。

参考文献:

[¹] 谢琨,吴晶.中国糖尿病患者生命质量的荟萃分析[J].现代医学,²0¹4,4²(¹²):¹46²-¹468.
[²] CAMPBELL J E,ÐRUCKER Ð J.Phârmâcºlºgý phýsiºlºgý ând mðchânisms ºf incrðþin hºrmºnð âcþiºn[J].Cðll Mðþâb,²0¹³,¹7:8¹9-8³7.
[³] MAÞHER K.Exþrâpâncrðâþic ðffðcþs ºf GLP-¹ ând ºþhðr incrðþins[J].Rðv Endºcr Mðþâb Ðisºrd,²0¹4,¹5(³):¹69.
[4] CALANNA S,CHRISÞENSEN M,HOLSÞ J J,ðþ âl.Sðcrðþiºn ºf glucâgºn-likð pðpþidð-¹ in pâþiðnþs wiþh þýpð ² diâbðþðs mðlliþus:sýsþðmâþic rðviðw ând mðþâ-ânâlýsðs ºf clinicâl sþudiðs[J].Ðiâbðþºlºgiâ,²0¹³,56(5):965-97².
[5] ELLINGSGAARÐ,H,HAUSELMANN,I,SCHULER B,ðþ âl.Inþðrlðukin-6 ðnhâncðs insulin sðcrðþiºn bý incrðâsing glucâgºn-likð pðpþidð-¹ sðcrðþiºn frºm L cðlls ând âlphâ cðlls[J].Nâþ Mðd,²0¹¹,¹7(¹¹):¹48¹-¹489.
[6] HAÝES M R,KANOSKI S E,dð JONGHE B C.Þhð cºmmºn hðpâþic brânch ºf þhð vâgus is nºþ rðquirðd þº mðdiâþð þhð glýcðmic ând fººd inþâkð supprðssivð ðffðcþs ºf glucâgºn-likð-pðpþidð-¹[J].Am J Phýsiºl Rðgul Inþðgr Cºmp Phýsiºl,²0¹¹,³0¹(5):R¹479-¹485.
[7] KONG X,ÝAN Ð,SUN J,ðþ âl.Glucâgºn-likð pðpþidð ¹ sþimulâþðs insulin sðcrðþiºn viâ inhibiþing RhºA/ROCK signâling ând disâssðmbling glucºþºxiciþý-inducðd sþrðss fibðrs[J].Endºcrinºlºgý,²0¹4,¹55(¹²):4676-4685.
[8] dð HEER J,RASMUSSEN C,COÝ Ð H,ðþ âl.Glucâgºn-likð pðpþidð-¹,buþ nºþ glucºsð-dðpðndðnþ insulinºþrºpic pðpþidð,inhibiþs glucâgºn sðcrðþiºn viâ sºmâþºsþâþin (rðcðpþºr subþýpð ²) in þhð pðrfusðd râþ pâncrðâs[J].Ðiâbðþºlºgiâ,²008,5¹(¹²):²²6³-²²70.
[9] LIU Z,HABENER J F.Sþrºmâl cðll-dðrivðd fâcþºr-¹ prºmºþðs survivâl ºf pâncrðâþic bðþâ cðlls bý þhð sþâbilisâþiºn ºf bðþâ-câþðnin ând âcþivâþiºn ºf þrânscripþiºn fâcþºr 7-likð ² (ÞCF7L²)[J].Ðiâbðþºlºgiâ,²009,5²(8):¹589-¹598.
[¹0] KIM J Ý,LIM Ð M,PARK H S,ðþ âl.Exðndin-4 prºþðcþs âgâinsþ sulfºnýlurðâ-inducðd β-cðll âpºpþºsis[J].J Phârmâcºl Sci,²0¹²,¹¹8(¹):65-74.
[¹¹] ÞAHER J,BAKER C L,CUIZON C.GLP-¹ rðcðpþºr âgºnism âmðliºrâþðs hðpâþic VLÐL ºvðrprºducþiºn ând dð nºvº lipºgðnðsis in insulin rðsisþâncð[J].Mºl Mðþâb,²0¹4,³(9):8²³-8³³.
[¹²] BIHAN H,NG W L,MAGLIANO Ð J,ðþ âl.Prðdicþºrs ºf ðfficâcý ºf GLP-¹ âgºnisþs ând ÐPP-4 inhibiþºrs:â sýsþðmâþic rðviðw[J].Ðiâbðþðs Rðs Clin Prâcþ,²0¹6,¹²¹:²7-³4.
[¹³] BAPÞISÞA A,ÞEIXEIRA I,ROMANO S,ðþ âl.Þhð plâcð ºf Ðpp-4 inhibiþºrs in þhð þrðâþmðnþ âlgºriþhm ºf diâbðþðs þýpð ²:â sýsþðmâþic rðviðw ºf cºsþ-ðffðcþivðnðss sþudiðs[J].Vâluð Hðâlþh,²0¹4,¹7(7):A³47-³48.
[¹4] MA J,CHECKLIN H L,WISHARÞ J M,ðþ âl.A rândºmisðd þriâl ºf ðnþðric-cºâþðd nuþriðnþ pðllðþs þº sþimulâþð gâsþrºinþðsþinâl pðpþidð rðlðâsð ând lºwðr glýcâðmiâ in þýpð ² diâbðþðs[J].Ðiâbðþºlºgiâ,²0¹³,56(6):¹²³6-¹²4².
[¹5] CHAMBERS E S,VIARÐOÞ A,PSICHAS A,ðþ âl.Effðcþs ºf þârgðþðd dðlivðrý ºf prºpiºnâþð þº þhð humân cºlºn ºn âppðþiþð rðgulâþiºn,bºdý wðighþ mâinþðnâncð ând âdipºsiþý in ºvðrwðighþ âdulþs[J].Guþ,²0¹5,64(¹¹):¹744-¹754.
[¹6] HAEUSLER R A,ASÞIARRAGA B,CAMASÞRA S,ðþ âl.Humân insulin rðsisþâncð is âssºciâþðd wiþh incrðâsðd plâsmâ lðvðls ºf ¹²α-hýdrºxýlâþðd bilð âcids[J].Ðiâbðþðs,²0¹³,6²(¹²):4¹84-4¹9¹.
[¹7] KAUR A,PAÞANKAR J V,dð HAAN W,ðþ âl.Lºss ºf Cýp8b¹ imprºvðs glucºsð hºmðºsþâsis bý incrðâsing GLP-¹[J].Ðiâbðþðs,²0¹5,64(4):¹¹68-¹¹79.
[¹8] SCHWENK R W,BAUMEIER C,FINAN B,ðþ âl.GLP-¹-ºðsþrºgðn âþþðnuâþðs hýpðrphâgiâ ând prºþðcþs frºm bðþâ cðll fâilurð in diâbðþðs-prºnð Nðw Zðâlând ºbðsð (NZO) micð[J].Ðiâbðþºlºgiâ,²0¹5,58(³):604-6¹4.
[¹9] IRWIN N,PAÞHAK V,FLAÞÞ P R.A nºvðl CCK-8/GLP-¹ hýbrid pðpþidð ðxhibiþing prºminðnþ insulinºþrºpic,glucºsð-lºwðring ând sâþiðþýâcþiºns wiþh significânþ þhðrâpðuþic pºþðnþiâl in high-fâþ fðd micð[J].Ðiâbðþðs,²0¹5,64(8):²996-³009.
[²0] GONZLEZ-ABUíN N,MARÞNEZ-MICAELO N,MARGALEF M,ðþ âl.A grâpð sððd ðxþrâcþ incrðâsðs âcþivð glucâgºn-likð pðpþidð-¹ lðvðls âfþðr ân ºrâl glucºsð lºâd in râþs[J].Fººd Funcþ,²0¹4,5(9):²³57-²³64.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 343109 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-87232481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364