>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息：
哈萨克族原发性高血压患者血清胆红素及血脂水平的分析
作者：陶杰1  王忠2  陈少泽2  张明1  张卫华1 
单位：1. 石河子大学医学院, 新疆 石河子 832002;
2. 石河子大学医学院 第一附属医院, 新疆 石河子 832002
关键词：原发性高血压 哈萨克族 血清胆红素 体重指数 血脂 性别 
分类号：R544.11
出版年·卷·期（页码）：2017·36·第二期（209-213）
摘要：

目的：研究哈萨克族原发性高血压（EH）患者血清胆红素与血压、血脂的关系，并探讨胆红素水平的性别差异。方法：选取2014年11月至2015年4月接受流行病学调查的新疆哈萨克族人群267人作为研究对象，根据血压分为EH组（128例）和血压正常组（139例），对比分析各组总胆红素（TBIL）、直接胆红素（DBIL）、间接胆红素（IBIL）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C），计算体重指数（BMI）；另外根据性别将两组人群各分为两个亚组，对比分析各组血清胆红素水平。结果：与正常组比较，EH组TBIL、DBIL均较低（P<0.05），年龄、BMI、TC、LDL-C均较高（P<0.05）。各亚组组间比较，EH组女性较正常组女性TBIL、DBIL、IBIL均降低（P<0.05），较EH组男性，TBIL、DBIL均降低（P<0.05）。相关分析显示TBIL、DBIL与LDL-C呈负相关（r分别为-0.176、-0.233，P均＜0.05），DBIL与TC呈负相关（r=-0.192，P<0.05）。结论：新疆哈萨克族EH患者的血清胆红素水平降低，BMI、TC、LDL-C升高；血清总胆红素及直接胆红素与血压有一定的相关性，并可能是哈萨克族女性患EH的危险因素；血清TBIL、DBIL可能是通过影响血脂代谢而影响血压的。

Objective: To investigate the relationship between serum bilirubin levels and blood pressure, lipids in the Kazak patients with essential hypertension(EH), and explore the gender differences of serum bilirubin levels. Methods: 128 cases of EH and 139 cases of health controls were collected from Xinjiang Kazak population through epidemiological investigation from November 2014 to April 2015,the serum total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),triglycerides(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) were measured,and body mass index(BMI) were calculated; and the serum bilirubin levels were analyzed in male and women groups. Results: The TBIL, DBIL in EH group were lower than those in control group(P<0.05), but the age,BMI,TC,LDL-C were higher(P<0.05). The TBIL, DBIL, IBIL in women EH group were lower than those in women control and the male in EH group(P<0.05).Pearson relation analysis showed that TBIL and DBIL were negatively correlated with LDL-C(r values were-0.176,-0.233, respectively,P<0.05, overall), and DBIL also negatively correlated with TC(r=-0.192, P<0.05). Conclusion: The serum TBIL and DBIL have a certain correlation with blood pressure, and may become a risk factors for women of the Kazak patients with EH;Serum TBIL and DBIL may affect the blood pressure through blood lipid metabolism.
参考文献：

[1] RODRIGUES C,ROCHA S,NASCIMENTO H,et al.Bilirubin levels and redox status in a young healthy population [J].Acta Haematol,2013,130(1):57-60.
[2] 王瑞涛,孟松艳,杨奕,等.老年冠心病患者血清胆红素和超敏C反应蛋白水平的变化分析[J].现代医学,2011,39(1):32-35.
[3] LIN J P,O'DONNELL C J,SCHWAIGER J P,et al.Association between the bilirubin levels and coronary heart disease in the Framingham Heart Study[J].Circulation,2006,114(14):1476-1481.
[4] WANG L,BAUTISTA L E.Serum bilirubin and the risk of hypertension[J].Int J Epidemiol,2015,44(1):142-152.
[5] HORSFALL L J,NAZARETH I,PETERSEN I.Cardiovascular events as a function of serum bilirubin levels in a large,statin-treated cohort[J].Circulation,2012,126(22):2556-2564.
[6] 陈天萌,曹剑,刘霖,等.老年高血压患者胆红素水平的变化与心功能的关系[J].中华老年心脑血管病杂志,2012,14(2):149-154.
[7] 江小柯,范竹萍,陈志威,等.胆红素浓度与冠心病和高血压病发生风险的相关性[J].中国肝脏病学杂志,2013,18(6):365-368.
[8] ZHOU T,CHEN X,LI Z,et al.Relationship between serum bilirubin and left ventricular hypertrophy in patients with essential hypertension[J].PLoS One,2015,10(4):e0125275.
[9] 马晓佳,张眉,郭淑霞,等.新疆农村地区维吾尔族、哈萨克族与汉族人群高血压患病率[J].中华高血压杂志,2013,21(12):1164-1168.
[10] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-743.
[11] 中国血压测量工作组.中国血压测量指南2011[J].中华高血压杂志,2011,19(12):1101-1113.
[12] CERIELLO A.Possible role of oxidative stress in the pathogenesis of hypertension [J].Diabetes Care,2008,31(Suppl 2):S181-184.
[13] LANONE S,BLOC S,FORESTI R,et al.Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase:implications for protection against endotoxic shock in rats[J].Faseb J,2005,19(13):1890-1892.
[14] TAILLE C,EL-BENNA J,LANONE S,et al.Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferation effect of carbon monoxide in human airway smooth muscle[J].Biol Chem,2005,280(27):25350-25360.
[15] GREABU M,OLINESCU R,KUMMEROW F A,et al.The levels of bilirubin maybe related to an inflammatory condition in patients with coronary heart disease[J].Acta Pol Pharm,2001,58(3):225-231.
[16] ERDOGAN D,GULLU H,YILDIRIM E,et al.Low serum bilirubin levels are independently and inversely related to impaired flow mediated vasodilation and increased carotid intima-media thickness in both men and women[J].Atherosclerosis,2006,184(2):431-437.
[17] 唐业勤.106例CAPD患者血清直接胆红素与营养、血压的相关性分析[D].长沙:中南大学,2014:1-25.
[18] 陈启才,肖娟,张鹏鹏,等.血清直接胆红素与代谢综合征及其组分关系的研究[J].中华流行病学杂志,2016,37(4):486-490.
[19] NAKAGAMI T,TOYOMURA K,KINOSHITA T,et al.A beneficial role of bile pigments as an endogenous tissue protector:anticomplement effects of biliverdin and conjugated bilirubin[J].Biochim Biophys Acta,1993,1158(2):189-193.
[20] 李晶玮,杜凤和,徐秀英.冠心病患者胆红素水平的性别差异[J].中国误诊学杂志,2010,10(28):6845-6846.
[21] 宋玲莉,傅增泮,刘海光.80例高血压患者血清胆红素临床分析[J].实用临床医学,2007,8(3):18-22.
[22] 廖淑萍,孙岩,施剑萍.中青年体重异常女性胆红素与血脂及血压关系探讨[J].广东医学,2010,31(14):1859-1861.
[23] 孙岩,廖淑萍,柳阳.总胆红素与老年高血压患者低密度脂蛋白及白蛋白关系的探讨[J].成都医学院学报,2009,4(4):270-273.
[24] 芮东升,郭恒,张景玉,等.膳食与行为因素及交互作用和新疆哈萨克族原发性高血压的关系[J].中华高血压杂志,2014,22(5):479-482.
服务与反馈：
【文章下载】【发表评论】【查看评论】【加入收藏】
提示：您还未登录，请登录！点此登录
您是第 468466 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话：025-83272481 83272483
电子邮件： bjb@pub.seu.edu.cn

本系统由北京博渊星辰网络科技有限公司设计开发 技术支持电话：010-63361626

苏ICP备09058364