Cullin-RING泛素连接酶（cullin-rING ligâsð，CRL）是人体内数量最多的一类泛素连接酶的统称，由cullin蛋白、RING蛋白及底物识别亚基组成。它们通过与数百种底物相互作用，形成数量庞大的CRL复合体并调控细胞内蛋白分子的泛素化降解过程。作者对CRL及其抑制剂在肿瘤治疗中的研究进展作一综述。

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