Objective:To observe the clinical efficacy and safety of 89 SrCl2combined with zoledronic in treatment of prostate cancer with bone metastasis.Methods:One hundred and eighty-three cases of prostate cancer with bone metastasis were randomly divided into 3 groups:89SrCl2 combined with zoledronic acid group (group A,68 cases), 89SrCl2 combined with99Tc-MDP group (group B,64 cases) and 89SrCl2 alone group (group C,51 cases).The occurrence of bone pain,bone metastasis,quality of life improvement and adverse reactions of the 3 groups were observed.Results:After treatment,the remission rate of bone pain ingroup A (88.23%) was higher than that in group B (75.00%,P=0.049) and group C (68.63%,P=0.008).The reduction rate of bone metastasis in group A was 48.53%,significantly higher than that in group C (29.41%,P=0.035);the quality of life improved rate in group A was 61.76%,significantly higher than that in group C (41.18%,P=0.004);there were no statistically significant differences for the remission rate of bone pain,rate of decrease of bone metastasis,and quality of life improvement between the group B and group C and there was no significant difference in the adverse reactions in the 3 groups.Conclusion:89SrCl2 combined with zoledronic acid therapy can relieve bone pain and bone metastasis,and improve quality of life without additional adverse reactions,and it's worth clinical promotion. |
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