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心肌梗死患者Lp-PLA2基因Y160X位点多态性检测的意义
作者:张明明1  于悦卿1  赵培1  杨朝菊1  高伟1  李亚丽2  李芳3 
单位:1. 河北省人民医院 检验科, 河北 石家庄 050051;
2. 河北省人民医院 生殖遗传科, 河北 石家庄 050051;
3. 河北省人民医院 风湿免疫科, 河北 石家庄 050051
关键词:脂蛋白相关磷脂酶A2基因 基因多态性 心肌梗死 遗传易感性 
分类号:R446.1;R541.4
出版年·卷·期(页码):2017·36·第一期(40-43)
摘要:

目的:检测Lp-PLA2基因Y160X位点突变与心肌梗死(MI)的关系。方法:检测病例组和对照组Lp-PLA2基因多态性,Logistic回归分析Lp-PLA2多态性与MI的关系,以及病例组和对照组血脂、血糖、Lp-PLA2、超敏C反应蛋白(HsCRP)、白介素-6(IL-6)、白介素-10(IL-10)水平,分析这些指标与MI及Lp-PLA2基因突变的关系。结果:病例组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDLC)、Lp-PLA2、HsCRP、IL-6水平及家族史阳性率高于对照组,HDLC、IL-10水平低于对照组(P<0.05);发病1周、1个月时Lp-PLA2、HsCRP、IL-6水平下降,IL-10水平上升(P<0.05)。Lp-PLA2基因型是MI的独立危险因素。结论:Lp-PLA2基因Y160X位点突变可能是MI的原因。

Objective:To investigate the relationship between Y160X site polymorphism of Lp-PLA2 gene and myocardial infarction(MI).Methods:Y160X site polymorphism of Lp-PLA2 gene was tested in case group and control group.Logistic regression analysis was used to analyze relationship between Y160X site polymorphism of Lp-PLA2 gene and MI.Serum Lp-PLA2,lipids,glucose,HsCRP,IL-6,IL-10 of the 2 groups were detected simultaneously.Results:The serum levels of TC,TG,LDL-C,Lp-PLA2,HsCRP,IL-6,and positivie rate of family history in case group were higher than those in control group;while the levels of HDL-C,IL-10 were lower than those in control group (P<0.05).Levels of Lp-PLA2,HsCRP,IL-6 decreased after 1 week,1month,whereas the level of IL-10 increased (P<0.05).Genotype of Lp-PLA2 gene was risk factor of MI.Conclusions:The Y160X(T/A) site polymorphism of LP-PLA2 gene may be one pathogeny of MI.

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