血清WFA<sup>+</sup>-M2BP对肝纤维化和肝硬化诊断价值的meta分析-东南大学学报医学版

血清WFA⁺-M2BP对肝纤维化和肝硬化诊断价值的meta分析

单位：1. 湖北中医药大学, 湖北武汉 430065;
2. 武汉大学附属湖北省第三人民医院中西医结合肝病科, 湖北武汉 430032

分类号：R446.11

出版年·卷·期（页码）：2017·36·第一期（34-39）

摘要：

目的：评价血清多花紫藤凝集素阳性Mac-2结合蛋白（WFA⁺-M2BP）对肝纤维化及肝硬化的诊断价值。方法：对PubMed、Ovid以及中国生物医学文献数据库、维普数据网中有关WFA⁺-M2BP诊断肝纤维化及肝硬化的中、英文文献进行筛选和评价，采用Stata13.0软件对入选文献数据进行分析。结果：共纳入6篇英文文献（包含927例患者）。Meta分析结果显示：（1）WFA⁺-M2BP诊断进展期肝纤维化的合并敏感度为0.78[95%CI（0.67~0.86）]、合并特异性为0.86[95%CI（0.77~0.92）]、阳性似然比为5.50[95%CI（3.60~8.60）]、阴性似然比为0.26[95%CI（0.18~0.37）]、诊断比值比为22[95%CI（14~34）]、受试者曲线下面积为0.89[95%CI（0.86~0.91）]；（2）WFA⁺-M2BP诊断早期肝硬化的合并敏感度为0.85[95%CI（0.70~0.94）]、合并特异性为0.90[95%CI（0.62~0.98）]、阳性似然比为8.40[95%CI（2.10~33.6）]、阴性似然比为0.16[95%CI（0.08~0.32）]、诊断比值比为51[95%CI（17~151）]、受试者曲线下面积为0.92[95%CI（0.90~ 0.94）]。结论：血清WFA⁺-M2BP对肝纤维化及肝硬化有较高的诊断价值。

Objectives:To evaluate the diagnostic value of WFA⁺-M2BP in patients with hepatic fibrosis or liver cirrhosis.Methods:A literature search was conducted from the PubMed,Ovid and China Biological Medicine Database (CBM),VIP data network (VIP).The databases were used to identify the Chinese or English literature which were related with the use of WFA⁺-M2BP in the diagnosis of patients with hepatic fibrosis or liver cirrhosis.The software-Stata version 13.0 was used to analyze the data.Results:A total of six English articles involving 927 patients were identified.The results showed that:(1)The results of Sen,Spe,+LR,-LR,DOR,AUC for WFA⁺-M2BP to diagnose advanced hepatic fibrosis were 0.78[95%CI(0.67~0.86)],0.86[95%CI(0.77~0.92)],5.50[95%CI(3.60~8.60)],0.26[95%CI(0.18~0.37)],22[95%CI(14~34)] and 0.89[95%CI(0.86~0.91)],respectively.(2)The results of Sen,Spe,+LR,-LR,DOR,AUC for WFA⁺-M2BP to diagnose early-stage liver cirrhosis were 0.85[95%CI(0.70~0.94)],0.90[95%CI(0.62~0.98)],8.40[95%CI(2.10~33.6)],0.16[95%CI(0.08~0.32)],51[95%CI(17~151)] and 0.92[95%CI(0.90~0.94)],respectively.Conclusion:WFA⁺-M2BP has a high diagnostic value for hepatic fibrosis and liver cirrhosis.

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