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胃癌组织中Vav1蛋白表达与胃癌临床生物学行为及预后的关系
作者：范立侨  谭明  李勇  檀碧波  王冬  刘庆伟 
单位：河北医科大学第四医院 外三科, 河北 石家庄 050011
关键词：胃癌 Vav1蛋白 侵袭 转移 预后 
分类号：R735.2
出版年·卷·期（页码）：2017·36·第一期（4-8）
摘要：

目的：探讨胃癌组织中Vav1蛋白表达与肿瘤临床生物学行为及预后的关系，并对Vav1蛋白与转移相关蛋白MMP-2、TIMP-1的关系进行分析。方法：采用免疫组织化学方法检测Vav1、MMP-2、TIMP-1蛋白在胃癌及癌旁组织中的表达，收集患者的临床资料并进行随访。结果：Vav1、MMP-2蛋白在胃癌组织中的阳性表达率高于癌旁组织（均P<0.01），TIMP-1蛋白在胃癌组织中表达低于癌旁组织（P<0.01）。Vav1蛋白与肿瘤分化程度、浸润深度、淋巴结转移、TNM分期相关（P<0.05）。Vav1阳性表达患者5年生存率为26.26%，明显低于阴性表达患者（50.82%）（均P<0.05）。Cox比例风险回归显示，Vav1阳性表达是影响患者预后的独立危险因素（P<0.05）。Vav1与MMP-2存在正相关关系（P<0.05）。结论：Vav1与胃癌的侵袭转移有关，Vav1阳性表达是胃癌预后差的标志。

Objective:To explore the relationship between the expression of Vav1 protein and clinical biological behavior,prognosis of gastric cancer,and to analysize of the relationship among Vav1 protein MMP-2 and TIMP-1 of the metastasis associated protein.Methods:Expressions of Vav1,MMP-2,TIMP-1 proteins in gastric cancer and paracancerous tissues were tested by immunohistochemistry.Data of clinicopathological characteristics and follow-up were also collected.Results:The expressions of Vav1,MMP-2 in gastric cancer were higher than in paracancerous tissue(all P<0.01),whereas expression of TIMP-1 was lower in gastric cancer than in paracancerous tissues(P<0.01).The expression of Vav1 in gastric cancer was correlated with the tumor differentiation,tumor infiltration depth,lymph node metastasis and TNM stage(all P<0.05).Five years survival rate in patients with Vav1 positive was 26.26%,and the negative was 50.82%(P<0.05).Cox proportional hazard regression showed that the positive expression of Vav1 was an independent risk factor affecting the prognosis of patients(P<0.05).The expression of Vav1 was positive correlated with MMP-2(P<0.05).Conclusion:Vav1 is involved in the invasion,metastasis of gastric cancer,and positive expression of Vav1 may be an independent risk factor for the prognosis of patients with gastric cancer.
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