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细菌-脑-肠轴理论体系的建立
作者:白宇1  胡云霞1  陈俊伟1  于希忠2  方南元2 
单位:1. 南京中医药大学, 江苏 南京 210023;
2. 南京中医药大学 第一临床医学院, 江苏 南京 210023
关键词:细菌-脑-肠轴 肠黏膜屏障 胃肠激素 短链脂肪酸 综述 
分类号:R333
出版年·卷·期(页码):2016·35·第五期(781-785)
摘要:

肠道菌群可以经脑-肠轴对大脑产生影响,因而形成了细菌-脑-肠轴这一概念。细菌-脑-肠轴的作用在代谢性疾病、精神性疾病、功能性胃肠病等疾病中均有体现,所涉及的途径包括肠黏膜屏障、神经信号通路、5-羟色胺和色氨酸代谢通路、免疫应答反应、胃肠激素、细菌代谢产物、基因调控、HPA轴等。本文作者就菌-脑-肠轴这一理论的形成和理论基础作一综述。

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