Objective: To summarize the clinical characteristics of toxoplasma encephalitis in HIV-infected patients in order to provide reference for clinical diagnosis and treatment. Methods: Clinical data of 11 HIV-infected patients with toxoplasma encephalitis were analyzed from July 2010 to June 2015 in the Second Hospital Affiliated to Southeast University. Results: Symptoms of 11 cases were different. CD4 T lymphocytes levels were lower than 100 μl-1. There were 4 cases(4/11,36.4%). No specific changes were found in cerebrospinal fluid. Head MRI scan and the enhanced one showed there were single or multiple mass lesions with surrounding edema, and irregular annule after enhancement. Treatment with sulfamethoxazole complex and azithromycin is effective. After the acute treatment, maintenance treatment should be performed to prevent relapse. Conclusion: Toxoplasmic encephalitis frequently occurs in HIV-infected patients with CD4 T lymphocytes levels below 100 μl-1. Blood toxoplasma IgG antibody positive rate is not high in these patients. Diagnosis of this disease depends on imaging examination. Treatment with sulfamethoxazole complex and azithromycin is the first choice for these these patients. |