Objective:To evaluate the correlation of diagnostic performance of MRI in breast cancer with the expression of specific receptors and the characteristics of microvessel density (MVD). Methods:Records of 80 cases of patients with pathologically proven primary breast cancer, which were unilateral ones, were reviewed from February 2011 to May 2015 in our institution. All cases were evaluated by MRI preoperatively and tissue samples were collected for immunohistochemistry postoperatively. The signal of MRI, the expression of specific receptors and the characteristics of MVD were observed. Results:Of all the 80 tumors, there were 40 cases of burr-like edges (50.0%), 30 cases of irregular contours (37.5%), 10 cases of lobulated shape(12.5%); 10 cases of clear boundary contour (12.5%), 6 cases of partial fuzzy boundary(7.1%), 64 cases of completely fuzzy boundaries with the surrounding tissue adhesion (80.0%); 51 cases of presented internal necrotic lesions(63.75%), with long T1 and T2 signal and no significant enhancement sweep surface intensification; For the correlations analysis, burr-like edge of breast cancer was found to be correlated with ER, Ki-67 receptor expression; tumor necrosis and internal uniformity were found to be correlated with C-erbB-2, P53 and Her-2 receptor expression. There was a significant difference of MVD between burr-like and smooth edge timors as well as between different parts of cancer MVD with MRI diagnosis(P<0.01); Dynamic enhancement parameters early intensive rate, Tmax and curve type showed strong correlation. Conclusion:Diagnostic performance of MRI in breast cancer may reflect the expression of specific receptors and the condition of MVD to some extent, and may provide a guide to clinical treatment options, treatment monitoring and prognosis. |
[1] 杜峰,王苗,尹先哲,等.多西他赛联合替吉奥治疗复发转移性乳腺癌的临床研究[J].现代医学,2012,40(4):464-466.
[2] 曹小丽,石磊,门雁鸣,等.雌激素受体和孕激素受体在乳腺癌组织中的表达与超声造影增强特征的关系[J].中华实验外科杂志,2013,30(2):381-382.
[3] 许旭,孙敬岩,顾林,等.从表观遗传学角度探讨RAR-β2基因在乳腺癌发生中的作用[J].中国肿瘤临床,2010,37(23):1326-1329.
[4] 徐媛媛,冯玉梅.生长因子及其受体作为乳腺癌转移与预后血清标志物的临床价值[J].中国肿瘤临床,2010,37(4):234-237.
[5] 席晨辉,庄大勇,郑鲁明,等.术中冰冻切片联合快速免疫组织化学染色检测乳腺癌前哨淋巴结微转移的临床研究[J].中华乳腺病杂志:电子版,2011,5(4):408-418.
[6] 李少英,吴华聪,王辉林,等.受体型蛋白酪氨酸磷酸酶O基因甲基化与乳腺癌细胞株化疗敏感性的关系[J].中华乳腺病杂志:电子版,2014,8(5):334-340.
[7] 郏潜新,周丽娟,欧阳林,等.磁共振动态增强扫描评价恩度在乳腺癌中的抗血管生成与抗肿瘤作用[J].医学影像学杂志,2014,24(11):1915-1919,1923.
[8] PAIS A,BITON I E,MARGALIT R,et al.Characterization of estrogen-receptor-targeted contrast agents in solution,breast cancer cells,and tumors in vivo[J].Magn Reson Med,2013,70(1):193-206.
[9] BOISSERIE-LACROIX M,MacGROGAN G,DEBLED M,et al.Triple-negative breast cancers:associations between imaging and pathological findings for triple-negative tumors compared with hormone receptor-positive/human epidermal growth factor receptor-2-negative breast cancers[J].Oncologist,2013,18(7):802-811.
[10] MA Q,NAKANE Y,MORI Y,et al.Multilayered,core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors[J].Biomaterials,2012,33(33):8486-8494.
[11] 吴冬梅,刘冠军.Her-2、ER、PR、NM 23、P 53和Ki 67在乳腺癌原发灶和复发转移灶中的表达及其临床意义[J].当代医学,2013,19(16):20-21.
[12] 张青,王振常,鲜军舫,等.乳腺癌增强MRI特征与病理、免疫组化指标的相关性研究[J].磁共振成像,2012,3(6):430-433.
[13] 郝亮,崔凤,任兴昌,等.基于ER、PR和Her2表达的乳腺癌亚型的MRI表现对照研究[C]//第十二次全国中西医结合医学影像学术研讨会论文集,2012:504-511.
[14] ABDELHAFEZ A,MONIR A.Diagnostic spectrum of ovarian masses in women with breast cancer;Magnetic resonance imaging:Histopathology correlation[J].Ann Diagn Pathol,2013,17(5):441-447.
[15] PAIS A,GUNANATHAN C,MARGALIT R,et al.In vivo magnetic resonance imaging of the estrogen receptor in an orthotopic model of human breast cancer[J].Cancer Res,2011,71(24):7387-7397.
[16] 郝亮,余日胜,崔凤,等.雌激素受体、孕激素受体和人类上皮因子受体2表达的乳腺癌亚型的MRI表现特征分析对照研究[J].中华医学杂志,2013,93(11):819-823.
[17] 于韬,罗娅红,何翠菊,等.乳腺癌MRI影像特征与C-erbB-2、ER、PR表达的相关性研究[C]//中华医学会放射学分会第三届全国乳腺学术会议暨长安医学影像论坛(2011陕西省放射学年会)论文集,2011:116-120. |
