抗SSA抗体阳性患者临床及神经影像学分析-东南大学学报医学版

抗SSA抗体阳性患者临床及神经影像学分析

单位：南方医科大学南方医院神经内科, 广东广州 510515

分类号：R392;R741

出版年·卷·期（页码）：2016·35·第五期（723-726）

摘要：

目的：探讨抗SSA抗体阳性患者的临床特点及神经影像学特征，提高医生对该抗体临床意义的认识。方法：对我院2015年3月15日至2016年1月15日抗SSA抗体阳性患者的临床资料进行回顾性分析。结果：共308例抗SSA抗体阳性患者，其中男77例，女231例，男女1：3。35~50岁组构成比高于其它组；系统性红斑狼疮患者有106例（34.42%），干燥综合征患者有52例（16.88%），类风湿性关节炎患者有10例（3.25%），视神经脊髓炎患者有7例（2.27%）；50例行影像学检查中10例正常，26例白质变性，9例缺血样改变，5例颈髓病变。54例患者合并神经系统损害。结论：抗SSA抗体阳性不能与干燥综合征划上等号。抗SSA抗体阳性患者更易合并神经系统损害，包括中枢性（脑、脊髓）损害及周围性（周围神经、肌肉）损害，神经影像学表现以皮层下白质及室旁白质病变为主。

Objective:To investigate clinical and neuroimaging features of patients with positive anti-SSA antibody on, so as to improve clinician awareness of the significance. Method:Hospitalized patients with positive anti-SSA antibody during March 15, 2015 and January 15, 2016 of our hospital were enrolled. Results:Among 308 patients enrolled, 77 were males and 231 females, with a male to female ratio 1:3. Those being 35-50 year-old constitute a big portion. Clinical characteristics of patients varied, including 106 cases of SLE (34.40%), 52 cases of SS (16.80%), 10 cases of RA (3.20%). A total of 50 patients underwent MRI/CT scan, 10 cases were negative, 26 cases with white matter lesions (52%). Also, we found 54 cases with neurologic involvement, including central nervous system involvement in 24 cases, peripheral nervous system involvement in 30 cases. Conclusion:Positive anti-SSA antibody are not necessarily indicating SS only. According to our study, positive anti-SSA antibody was much more common in patients with SLE. Neurological imaging mainly showed white matter and subcortical white matter lesions. This antibody needs a comprehensive examination of the autoantibodies and comprehensive analysis of clinical manifestations.

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