Objective: To analyze the expression information of three independent researches to explore differential genes in the progress of alzheimer disease(AD)and providing a basis for the AD prevention. Methods: Raw data were downloaded from NCBI databases and imported to "Expression Console" to standardize the data and then the results were output to "Transcriptome Analysis Console" for data analysis. After that all different genes were imported to online analysis tools DAVID, ToppGene, STRING for further analyze. Results: The studies included in our research all used human brain hippocampus sample. Through further analysis, 24 differentially expressed genes were analyzed, among which 18 genes were increased and 6 were down-regulated. Through further analysis, two genesNEFM and SV2B were found to be closely related to synapses signal transduction. Conclusion: The pathogenesis of AD may be closely related with NEFM and SV2B genes. Nevertheless, specific experiment will be needed to verify the geness. |