脊髓损伤是一种严重的外伤性疾病,可以导致永久性的运动和感觉功能丧失。由于病变部位及周围不利于脊髓损伤修复的微环境,脊髓损伤的治疗没有有效的策略。此外,胶质瘢痕形成和炎症反应抑制轴突生长,形成抑制脊髓损伤修复的屏障。水凝胶目前是一种理想的运输工具,因为它可以模仿细胞外基质给细胞提供支持,促进其增殖、迁移、分化,引导植入的神经组织修复和替代受损组织。通过水凝胶将细胞和分子运输到损伤部位具有广阔的前景,并被应用于脊髓损伤修复。本文中作者将介绍水凝胶作为运载工具的特点和优势,及水凝胶在细胞及细胞分子植入脊髓损伤部位的应用。

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