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雌激素受体ERα及ERβ与肿瘤关系的研究进展
作者:赵谊宁1  陶陶1  张力杰2  陈恕求2  姜华2  陈明2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 泌尿外科, 江苏 南京 210009
关键词:雌激素受体 基因组 肿瘤 综述 
分类号:R339;R73
出版年·卷·期(页码):2016·35·第三期(418-422)
摘要:

雌激素受体α(ERα)和雌激素受体β(ERβ)是参与调节人体多种复杂生理学反应的转录因子,雌激素受体(ER)信号转导通路的异常与乳腺癌、卵巢癌、前列腺癌、结肠癌等多种肿瘤的发生及发展密切相关。本篇综述以与ER功能相关的全基因组数据为背景,回顾并且更新了ERα和 ERβ 与临床常见肿瘤关系的最新进展。总体来说,ERα在肿瘤中扮演着类似肿瘤启动因子的角色,而ERβ在肿瘤中扮演了类似肿瘤抑制因子的角色。本文中作者也讨论了目前这两种受体可能存在的临床应用及其所面临的挑战。

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