Objective:To study the effects of radiofrequency thermocoagulation on cardiac effects and ocular surface for the patients with trigeminal neuralgia. Methods:80 cases of patients were diagnosed with trigeminal neuralgia in our hospital from March 2010 to December 2014. 42 patients in the study group were treated by radiofrequency thermocoagulation, and the other 38 patients in the control group were treated by surgical treatment. The effects on cardiac effects and ocular surface were compared between the two groups. Results:The corneal sensation sensitivity decreased in both of two groups(F=143.22, P=0.000;t=9.725, P=0.000). Corneal sensation sensitivity in the study group was significantly lower than that in control group 3 days and a month after surgery(t=6.761, P=0.000;t=10.578, P=0.000). Tear secretion was showing a decreasing trend in the study group before and after surgery(F=18.490, P=0.000), the length of filter paper infiltrated for Schirmer Ⅰ test in the study group was significantly shorter than that in the control group(t=5.385, P=0.000). The BUT value decreased after surgery in the study group(F=3.176, P=0.045). There were no significant differences for the BUT value between two groups before and after surgery(t=0.000, 0.956, 1.567;P=1.000, 0.342, 0.121). The corneal fluorescein coloring was significantly increased 3 days and one month after surgery in both groups(F=163.218, 38.535;P=0.000, 0.000), and the scores in the study group were significantly higher than those in the control group(t=6.842, 7.377;P=0.000, 0.000). The relative density of corneal subepithelial nerve fibers was decreased in the study group(F=24.559, P=0.000), and the corneal subepithelial nerve fibers relative density was significantly lower than that in the control group one month after surgery(t=2.199, P=0.032). Arrhythmia occurred in both groups and the incidence of arrhythmia in the study group was much lower than that in the control group(P<0.05). Conclusion:Compared with avulsion, patients treated with radiofrequency thermocoagulation will have less tear secretion and high instability of the tear film, a variety of arrhythmias will happen in the surgery, timely intervention and treatment should be done after surgery, and electrocardiogram monitoring during operation should be done to ensure the safety of patients and reduce patients' discomfort and improve their quality of life.