贵州少数民族女性特发性骨质疏松的临床特点及其相关因素调查-东南大学学报医学版

贵州少数民族女性特发性骨质疏松的临床特点及其相关因素调查

单位：1. 北京体育大学运动人体科学学院, 北京 100084;
2. 贵州师范大学体育学院, 贵州贵阳 550001;
3. 贵阳医学院附属医院骨科, 贵州贵阳 550000

分类号：R195

出版年·卷·期（页码）：2016·35·第二期（180-183）

摘要：

目的:分析贵州少数民族女性特发性骨质疏松的临床特点及其相关因素,为预防和减少特发性骨质疏松的发生提供参考。方法:回顾性分析73例贵州少数民族女性特发性骨质疏松患者的临床资料,采用统一问卷对生活方式进行调查。结果:女性特发性骨质疏松患者发病时间为孕期或哺乳期,常表现为腰背部酸痛及臀部疼痛,多数患者骨密度检测结果为骨质疏松(87.7%),少数患者骨量减少(12.3%)。实验室检查患者碱性磷酸酶、甲状旁腺素、总胆固醇、低密度脂蛋白胆固醇水平增高。治疗2周后碱性磷酸酶、甲状旁腺素、总胆固醇、低密度脂蛋白胆固醇水平与治疗前比较明显降低(P<0.01),血钙、血磷、尿酸及C反应蛋白变化不明显(P>0.05)。发病原因与孕期或哺乳期饮食及生活方式具有一定的相关性。结论:应保证妊娠期和哺乳期妇女的合理营养,适当户外运动和日光照射可预防女性特发性骨质疏松的发生。

Objective:To analyze the clinical characteristics and lifestyle related factors in Guizhou minority women with idiopathic osteoporosis, in order to prevent and reduce the occurrence of idiopathic osteoporosis. Methods:The clinical data of 73 Guizhou minority women of idiopathic osteoporosis were retrospectively analyzed. A uniform questionnaire survey of lifestyle was performed. Results:The occurrence time of women with idiopathic osteoporosis was the pregnancy or lactating period, the common clinical manifestations included lower back pain and hip pain. Most of patients had osteoporosis(87.7%), and 12.3% of patients showed bone mass loss. The results of laboratory test showed the serum alkaline phosphatase, parathyroid hormone, total cholesterol and low density lipoprotein cholesterol levels increased. After the drugs treatment for 2 weeks, compared with pre-treatment, the levels of serum alkaline phosphatase, parathyroid hormone, total cholesterol and low density lipoprotein cholesterol decreased significantly(all P<0.01), and the changes of serum calcium, serum phosphate, uric acid and C-reactive protein levels were insignificant(all P>0.05). The causes of the disease were partly related to the diet and the lifestyle during the pregnancy and lactating period. Conclusion:Proper nutrition during the pregnancy and lactating period, adequate outdoor exercise and sunlight can prevent the occurrence of idiopathic osteoporosis in women.

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