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炎症引起非甲状腺疾病综合征的机制研究进展
作者:王超群  刘志民 
单位:第二军医大学附属长征医院, 上海 200003
关键词:非甲状腺疾病综合征 炎症 脱碘酶 文献综述 
分类号:R581
出版年·卷·期(页码):2016·35·第一期(130-135)
摘要:

非甲状腺疾病综合征(nonthyroid illness syndrome,NTIS)在住院患者中较为常见。以炎症因子为起始因素,下丘脑、垂体和各外周器官脱碘酶的改变导致下丘脑-垂体-甲状腺(HPT)轴调定点下调、靶器官甲状腺激素变化是NTIS发生的重要机制。但近来研究发现NTIS早期可能是一种急性期反应,特别是甲状腺激素结合蛋白的下降和甲状腺激素转运体的改变在NTIS的形成中起了重要作用。目前对NTIS是否需要治疗尚不明确,深入了解NTIS的病理生理机制和局部器官组织功能状态为寻求NTIS的治疗方法所必需。

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