三种膳食纤维对脂代谢紊乱大鼠糖脂代谢及氧化应激的作用-东南大学学报医学版

三种膳食纤维对脂代谢紊乱大鼠糖脂代谢及氧化应激的作用

单位：1. 东南大学公共卫生学院, 江苏南京 210009;
2. 扬州大学旅游烹饪学院, 江苏扬州 225001

分类号：R151.3

出版年·卷·期（页码）：2016·35·第一期（83-88）

摘要：

目的:探讨小麦、玉米和多种谷物与豆组合3种膳食纤维对脂代谢紊乱大鼠糖脂代谢及氧化应激的作用。方法:将48只SD大鼠随机分成阴性对照(NC)组、高脂模型(HF)组、小麦膳食纤维(W)组、玉米膳食纤维(C)组、多种谷物与豆组合膳食纤维(CSC)组和阳性对照(PC)组,每组8只,各组喂饲相应的饲料。8周后,测定大鼠血脂及血清和肝组织超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)、丙二醛(MDA)和超敏C反应蛋白(hs-CRP)水平。结果:3种膳食纤维能显著降低实验大鼠甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和空腹血糖(GLU)水平,C和CSC能显著升高高密度脂蛋白胆固醇(HDL-C)水平。CSC显著升高实验大鼠血清和肝组织SOD和T-AOC水平,显著降低血清MDA水平。W和C显著升高了实验大鼠肝组织SOD和T-AOC水平,但对血清SOD和T-AOC水平无显著性影响。3种膳食纤维均显著降低实验大鼠血清hs-CRP水平。结论:3种谷物膳食纤维,尤其是CSC膳食纤维,能够改善大鼠的糖脂代谢水平,对氧化应激和炎症因子有一定的调节作用。

Objective:To investigate the dietary fiber (DF) from wheat,corn,and cereal-soybean combination on glucolipid metabolism and oxidative stress in lipid metabolism disorder rats. Methods:48 SD rats were randomly divided into six groups:control (NC) group,high fat (HF)group,wheat DF (W)group,corn DF(C) group,cereal-soybean combination DF (CSC) group and positive (PC) group. After 8 weeks,the lipid level and the level of SOD,T-AOC,MDA,hs-CRP in rats' serum and liver tissue were determined. Results:The three kinds of DF significantly reduced TG, TC, LDL-C and GLU level of experimental rats, C and CSC significantly increased HDL-C levels. CSC markedly increased serum and liver tissue SOD and T-AOC levels, significantly reduced serum MDA level. W and C significantly increased liver tissue SOD and T-AOC levels, but had no significant effect on serum SOD and T-AOC level. Three kinds of DF significantly reduced serum hs-CRP levels of experimental rats. Conclusion:Three kinds of DF, especially DF of CSC, can improve the glucolipid metabolism, and adjust the oxidative stress and inflammation factors.

参考文献：

[1] 扈晓杰,韩杰,李铎.膳食纤维的定义、分析方法和摄入现状[J].中国食品学报,2011,11(3):133-137.
[2] 王慧君,张兵,杜文雯,等.1989-2006年中国九省(区)居民膳食纤维摄入状况及其变化趋势[J].中华预防医学杂志,2011,45(4):318-322.
[3] 刘洋,翟成凯,孙桂菊,等.谷豆复合物、谷豆复合膳食纤维及单一谷物膳食纤维对脂代谢紊乱的影响[J].卫生研究,2014,43(3):372-377.
[4] 陈学芬,翟成凯,姜玲,等.血脂异常人群不同LPL-PvuⅡ基因型对粗杂粮干预的敏感性[J].营养学报,2006,28(3):263-266.
[5] 翟成凯张群,王艳莉,等.过氧化物酶体增殖物激活受体r2基因多态性对血脂异常人群膳食干预效果的影响[J].中华预防医学杂志,2010,44(1):39-43.
[6] 丁舟波,王晓飞,翟成凯,等.复配式粗杂粮对大鼠胰岛素抵抗及PPAR-r表达的影响[J].卫生研究,2010,39(1):29-32.
[7] LATTIMER J M,HAUB M D.Effects of dietary fiber and its components on metabolic health[J].Nutrients,2010,2(12):1266-1289.
[8] GEMEN R,de VRIES J F,SLAVIN J L.Relationship between molecular structure of cereal dietary fiber and health effects:focus on glucose/insulin response and gut health[J].Nutr Rev,2011,69(1):22-33.
[9] VAHOUNY G V.Dietary fiber,lipid metabolism,and atherosclerosis[J].Fed Proc,1982,41(11):2801-2806.
[10] DIKEMAN C L,FAHEY G C.Viscosity as related to dietary fiber:a review[J].Crit Rev Food Sci,2006,46(8):649-663.
[11] MADAR Z.Effect of brown rice and soybean dietary fiber on the control of glucose and lipid metabolism in diabetic rats[J].Am J Clin Nutr,1983,38(3):388-393.
[12] LI J,KANEKO T,QIN L Q,et al.Long-term effects of high dietary fiber intake on glucose tolerance and lipid metabolism in GK rats:comparison among barley,rice,and cornstarch[J].Metabolism,2003,52(9):1206-1210.
[13] JUHEL C,TOSINI F,STEIB M,et al.Cholesterol-lowering effect of non-viscous soluble dietary fiber NUTRIOSE (R) 6 in moderately hypercholesterolemic hamsters[J].Indian J Exp Biol,2011,49(3):219-228.
[14] 朱莉,王庆玲,孟春棉,等.番茄皮渣膳食纤维的理化性质及其结构表征[J].现代食品科技,2014,30(11):60-64.
[15] 王艳丽,刘凌,孙慧,等.膳食纤维的微观结构及功能特性研究[J].中国食品添加剂,2014(2):98-103.
[16] 宋国彬,张弘,郑华,等.玛咖可溶性膳食纤维的制备及其表征[J].食品科学,2013,34(2):11-18.
[17] LOY S L,KNS S,JM H J.Increase in maternal adiposity and poor lipid profile is associated with oxidative stress markers during pregnancy[J].Prev Med,2013,57(Suppl):S41-S44.
[18] SANCHEZ-ALONSO I,JIMENEZ-ESCRIG A,SAURA-CALIXTO F,et al.Antioxidant protection of white grape pomace on restructured fish products during frozen storage[J].Food Sci Technol,2007,41(1):42-50.
[19] 秦杰,苗敬芝,唐仕荣.酶法提取生姜中可溶性膳食纤维及抗氧化活性的研究[J].中国食品添加剂,2010(6):103-106.
[20] 周小理,钱韻芳,周一鸣,等.不同处理工艺对苦荞麸皮膳食纤维体外抗氧化活性的影响[J].食品科学,2011,32(8):1-4.
[21] 王磊,袁芳,向俊,等.响应面法优化高压均质提取椪柑渣中可溶性膳食纤维及抗氧化活性研究[J].中国食品学报,2015(5):82-89.
[22] SAURA-CALIXTO F.Antioxidant dietary fiber product:a new concept and a potential food ingredient[J].J Agric Food Chem,1998,46(10):4303-4306.
[23] LECUMBERRI E,MATEOS R,IZQUIERDO-PULIDO M,et al.Dietary fibre composition,antioxidant capacity and physico-chemical properties of a fibre-rich product from cocoa (Theobroma cacao L.)[J].Food Chemistry,2007,104(3):948-954.
[24] LECUMBERRI E,GOYA L,MATEOS R,et al.A diet rich in dietary fiber from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic rats[J].Nutrition,2007,23(4):332-341.
[25] JIAO J,XU J Y,ZHANG W G,et al.Effect of dietary fiber on circulating C-reactive protein in overweight and obese adults:a meta-analysis of randomized controlled trials[J].Int J Food Sci Nutr,2015,66(1):114-119.
[26] XIE L M,GE Y Y,HUANG X,et al.Effects of fermentable dietary fiber supplementation on oxidative and inflammatory status in hemodialysis patients[J].Int J Clin Exp Med,2015,8(1):1363-1369.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录