Objective:To explore the protective effects of ginsenoside(GS) combined with dexamethasone(Dex) on concanavalin incuced liver injury rats mode and analyse the related mechanism.Methods:40 Wistar rats were randomly divided into five groups(n=8):model group, GS group, Dex group, GS+Dex group and control group.The rats model with actue hepatic injury induced by injection of concanavalin was established.GS group and Dex group were administered Dex and GS separately.GS+Dex group used co-administration of GS and Dex.Control group was not given any intervention.Serum alanine aminotransferase(ALT), aspartate aminotransferase(AST), malondialdehyde(MDA) and superoxide dismutase(SOD) levels were recorded and the expression of liver tissue nuclear transcription factor kappa B(NF-κB) P65 and tumor necrosis factor-α(TNF-α) and γ-interferon(IFN-γ) levels were analyzed.liver tissue was histopathologically examined with hematoxylin-exsin(HE) staining.Results:ALT and AST levels of the model group was significantly higher than control group(t=4.570,4.513;P<0.01).ALT and AST levels of GS group,Dex group and GS+Dex group were significantly lower than model group(P<0.05).The decreased level of ALT in GS+Dex group significantly greater than GS group and Dex group(t=2.263,3.072;P<0.05).The same as AST(t=2.829,2.765;P<0.05).MDA levels of the model group was significantly higher than control group and SOD activity was lower than control group (t=7.515,8.514;P<0.01).MDA levels and SOD activity had no significantly difference between GS group and model group(P>0.05).MDA levels and SOD activity had significantly difference between Dex group and GS+Dex group(t=2.287,2.722;P<0.05).The weight of rats in GS+Dex group was significantly greater than control group and GS group(t=2.942,2.327;P<0.05).Protein expression of NF-κB P65 of the model group was significantly higher than control group(t=9.428,P<0.01).The increased level of NF-κB P65 in GS+Dex group significantly greater than GS group and Dex group(t=6.428,5.246;P<0.05).TNF-α and IFN-γ levels of the model group was significantly higher than control group(t=19.235,25.171;P<0.01).The decreased level of TNF-α in GS+Dex group was significantly greater than GS group and Dex group(t=2.313,9.053;P<0.05).The same as IFN-γ levels(t=5.171,8.933;P<0.05).Conclusion:Ginsenoside combined with dexamethasone can effectively protect the liver function of concanavalin-induced liver injury in rats.The mechanism may be related to inhibition of oxidative stress and activity of NF-κB P65 which can reduce TNF-α and regulate immune function.