幼年皮肌炎患者血清脂质水平的临床研究-东南大学学报医学版

幼年皮肌炎患者血清脂质水平的临床研究

单位：南京医科大学附属淮安市第一人民医院免疫风湿科, 江苏淮安 223300

分类号：R593.25

出版年·卷·期（页码）：2016·35·第一期（21-25）

摘要：

目的:探讨幼年皮肌炎(JDM)患者血脂水平异常的发生率和危险因素。方法:对初诊JDM患者33例及同期健康体检儿童33例进行回顾性研究, JDM患者分为高脂血症组和非高脂血症组,观察初诊JDM患者血脂异常的发生率及危险因素。结果:12例JDM患者血脂异常,其中总胆固醇(TC)升高、甘油三酯(TG)升高、高密度脂蛋白胆固醇(HDL-C)降低例数分别是4例(33%)、5例(44%)、9例(77%)。JDM组C反应蛋白(CRP)水平与TC和HDL-C呈负相关(分别为r=-0.243、P=0.039和r=-0.354、P=0.007)。多因素矫正后,线性回归模型表明JDM患者CRP和HDL-C相关(P=0.029)。结论:初诊JDM患者存在脂质代谢紊乱,表现为TG、TC水平增高,HDL-C水平降低,提示高风险动脉粥样硬化的发生。JDM患者体内的炎症状态可能是HDL-C发生代谢紊乱的主要原因。

Objective:To investigate the changes of serum lipids and risk factors in juvenile dermatomyositis (JDM). Methods:By retrospective analysis,we investigated 33 cases with JDM divided into hyperlipidemia group and non-hyperlipidemia group who accepted the first treatment in our hospital,and assessed the incidence of dyslipoproteinemia and risk factors in JDM patients without any therapy. Results:Twelve patients complicated with dyslipoproteinemia.The rate of dyslipoproteinemia was TC 33% (4cases),TG 44%(5cases),HDL-C 77%(5cases). CRP level was negatively correlated with TC and HDL-C(r=-0.243P=0.039,r=-0.354P=0.007, respectively)in JDM patients.After multivariate adjustment,linear regression model demonstrated that CRP was associated with HDL-C among JDM patients (P=0.029). Conclusion:Dyslipidemia is a common feature in JDM patients that is characterized by a decrease in HDL-C and an increase in TG,TC,suggesting a high risk of atherosclerosis. The inflammatory condition in JDM may account for the metabolism of HDL-C.

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