目的:评价肺表面活性物质(PS)治疗新生儿重症肺炎的有效性及安全性,监测肺表面活性蛋白B(SP-B)在新生儿重症肺炎治疗前后的变化.方法:将48例重症肺炎新生儿分为治疗组(23例)和常规组(25例).两组患儿均给予机械通气治疗.治疗组同时给予PS治疗,气管内给药.结果:治疗组的氧合指数(OI)明显低于常规组,动脉/肺泡氧分压比值(a/APO2)明显高于常规组,差异有统计学意义(P<0.05).治疗组氧暴露时间明显小于常规组, 差异有统计学意义(P<0.05).治疗组机械通气时间小于常规组,差异有统计学意义(P<0.05).治疗组血清中及支气管肺泡灌洗液中SP-B的水平均显著高于常规组.两组患儿均治愈出院,无死亡病例.结论:PS治疗新生儿重症肺炎是有效的和安全的,可促进内源性肺表面活性物质的生成. |
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