γ干扰素诱导蛋白10对糖尿病合并活动性肺结核的辅助诊疗价值-东南大学学报医学版

γ干扰素诱导蛋白10对糖尿病合并活动性肺结核的辅助诊疗价值

作者：何花¹ 周玉皆² 冯枭¹ 宋梅梅¹ 文高艳¹ 朱珠¹ 黄磊¹ 费贤树¹ 袁广琴¹ 曾谊¹

单位：1. 南京市胸科医院鉴别诊断科, 江苏南京 210029;
2. 南京市鼓楼医院呼吸科, 江苏南京 210008

分类号：R587.1;R521

出版年·卷·期（页码）：2015·34·第六期（916-918）

摘要：

目的:探讨γ干扰素诱导蛋白10(IP-10)对糖尿病合并活动性肺结核诊疗的临床价值.方法:选取糖尿病合并活动性肺结核患者10例、活动性肺结核患者34例、非结核肺部疾病患者10例、糖尿病患者10例及健康志愿者12例,检测血IP-10质量浓度,在抗结核治疗2个月后复测糖尿病合并活动性肺结核组血IP-10质量浓度,并进行统计分析.结果:糖尿病合并活动性肺结核组抗结核治疗前后的IP-10质量浓度分别为(410.35±121.36)、(270.11±94.25)ng·L^-1,活动性肺结核组(195.61±70.71)ng·L^-1,非结核肺部疾病组(106.27±52.34)ng·L^-1,糖尿病组(112.77±32.47)ng·L^-1,健康组(48.12±31.43)ng·L^-1,糖尿病合并活动性肺结核组的IP-10质量浓度均高于其他4组,差异均有统计学意义(均P<0.01),糖尿病合并活动性肺结核组抗结核治疗2个月后血IP-10质量浓度低于抗结核治疗前,差异有统计学意义(P<0.01).结论:糖尿病合并活动性肺结核患者血IP-10质量浓度明显升高,经抗结核治疗后下降,其可作为诊断及评估抗结核治疗疗效的辅助指标.

Objective: To investigate the value of interferon-inducible protein-10 (IP-10) in clinical diagnosis and treatment of diabetes and active tuberculosis. Methods: 10 patients with diabetes and active tuberculosis,34 patients with active tuberculosis, 10 patients with non-tuberculosis pulmonary disease, 10 patients with diabetes, and 12 healthy volunteers were enrolled for serum IP-10 detection and statistical analysis. Serum IP-10 levels were re-examined in diabetes patients with active pulmonary tuberculosis who received anti-tuberculosis treatment for two months, and the statistical analysis was performed. Results: The serum IP-10 concentrations were (410.35±121.36), (195.61±70.71),(106.27±52.34),(112.77±32.47),(48.12±31.43)ng·L^-1in diabetes and active tuberculosis group, active tuberculosis group, non-tuberculosis pulmonary disease group, diabetes group and healthy volunteers group, respectively.The serum IP-10 concentrations in patients with diabetes and active tuberculosis were significantly higher than the other 4 groups (P<0.01).Diabetes with active pulmonary tuberculosis patients exhibited decreased serum IP-10 levels after anti-tuberculosis treatment for two months (P<0.01). Conclusion: Serum IP-10 concentration increases in patients with diabetes and active tuberculosis, and decreases after anti-tuberculosis treatment. IP-10 could be used as an auxiliary index in the diagnosis and treatment of diabetes and active tuberculosis.

参考文献：

[1] 赵玉荣,张培元,李金红.抗结核抗体检测及其结果分析[J].中国防痨杂志,2000,22(2):88-90.
[2] 中华医学会结核病学分会.肺结核诊断和治疗指南[J].中华结核和呼吸杂志,2001,24(2):70-74.
[3] 范梦柏,王秀娥,宋承平,等.细胞因子TNF-α、IFN-γ、IP-10对结核性胸腔积液诊断价值的研究[J].中国防痨杂志,2012,34(8):550-552.
[4] 潘燕玉,李津,程小星.肺结核患者特异性抗原反应性IP-10的表达特点[J].临床肺科杂志,2013,18(1):103-104.
[5] RUHWALD M,DOMINGUE Z J,LATORRE I,et al.A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis[J].Tuberculosis,2011,91(3):260-267.
[6] LATORRE I,DIAZ J,MIALDEA I,et al.IP-10 is an accurate biomarker for the diagnosis of tuberculosis in children[J].Infect,2014,69(6):590-599.
[7] KIBIKI G S,MYERS L C,KALAMBO C F,et al.Bronchoalveolar neutro-phils,interferon gamma-inducible protein 10 and interleukin-7 in AIDS-associated tuberculosis[J].CIin ExP Immunol,2007,148(2):254-259.
[8] KABEER B S,SIKHAMANI R,RAJA A,et al.Comparison of interferon gamma and interferon gamma-inducible protein-10 secretion in HIV-tuberculosis patients[J].AIDS,2010,24(2):323-325.
[9] AABYE M G,RUHWALD M,PRAYGOD G,et al.Potential of interferon-γ-inducible protein 10 in improving tuberculosis diagnosis in HIV-infected patients[J].Eur Respir J,2010,36(6):1488-1490.
[10] 黄建飞.肺结核合并糖尿病治疗进展[J].中国药物经济学,2013,2(1):365-368.
[11] 赵亚军,谭波.糖尿病合并肺结核病的临床探讨[J].中国现代医生,2009,47(13):139-140.
[12] 邓国炯,郭春辉.初治活动性肺结核T淋巴细胞亚群检测及其临床意义[J].现代医学,2007,35(6):468-470.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录