Objective: To analyze the distribution characteristic of the skeletal metastasis lesion in 99mTc-MDP bone scintigraphy and the correlation between serum tumor marker (CEA,NSE, CYFRA21-1 and CA125) and skeletal metastasis in small cell lung cancer. Methods: 56 cases with small cell lung confirmed by pathology were examined with 99mTc-MDP bone scintigraphy. Serum concentration of CEA, NSE, CYFRA21-1 and CA125 were measured one week before whole-body bone scanning. ROC curve and spearman correlation analysis were used to evaluate the serum tumor markers in diagnose the development of the skeletal metastasis. Results: 21 imaging positive lesions were identified as the skeletal metastasis. The distribution of the skeletal metastasis lesions were: chest(46.60%), spine(34.95%), pelvis(9.71%), four limbs(5.83%), skull(2.91%). CEA,NSE levels in bone metastasis group were significant higher than those in the negative group(P<0.05) and the area of ROC curve were 0.789 and 0.717 respectively(P<0.05). There was a correlation between concentration of CEA, NSE and classification of bone metastases. CEA and NSE level were the highest in the cases with wide spread bone metastasis. Conclusion: The bone metastasis lesions of small cell lung cancer are mostly seen in axial skeleton(chest and spine). The more number of bone metastasis lesions,the higher serum tumor markers level, the concentration of serum tumor markers for small cell lung cancer has certain reference significance to diagnose the occurrence and development of bone metastasis. |
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