5-羟色胺转运体基因多态性与冠心病合并抑郁相关性的Meta分析-东南大学学报医学版

5-羟色胺转运体基因多态性与冠心病合并抑郁相关性的Meta分析

单位：东南大学附属中大医院心内科, 江苏南京 210009

分类号：R541.4;R749.41

出版年·卷·期（页码）：2015·34·第五期（792-796）

摘要：

目的:通过Meta分析综合评价5-羟色胺转运体(5-HTT)基因多态性与冠心病合并抑郁的关系,为冠心病合并抑郁的遗传背景提供进一步证据。方法:计算机检索PubMed、Embase、Google学术、Web of Science、中国生物医学文献数据库、CNKI、万方等数据库,依据选择标准收集所有相关病例对照研究,应用RevMan 5.2.5软件对符合条件的研究结果进行Meta分析。结果:有3篇文献纳入本研究,纳入本研究的人群总数为3 230例,其中1 179例为冠心病合并抑郁,不合并抑郁组的人群有2 051例。分析显示,LL基因型在对照组中显示频率较高,可能是冠心病合并抑郁症的保护因子(OR=0.65,95%CI为0.50~0.83,P=0.000 6)。结论:5-HTT基因多态性与冠心病合并抑郁症存在关联,其中LL基因型可能为保护性因子。

Objective: To evaluate the associations of 5-HTT gene polymorphism with depression and coronary heart disease by Meta-analysis and to provide evidence for the genetic background of depression and coronary heart disease. Methods: We conducted a comprehensive search for articles from PubMed, Embas, Google Scholar, Web of Science, Chinese BioMedical Literature, CNKI databases and Wanfang databases. All related case-control studies were collected and the results were analyzed by RevMan 5.2.5 software. Results: A total of 1 179 cases and 2 051 controls were collected from 3 studies. The analysis showed that LL genotype showed a higher frequency in the control group(OR=0.65,95%CI 0.50-0.83,P=0.000 6), and it might be a protective factor of coronary heart disease with depression. Conclusion: Polymorphisms of 5-HTT gene have association with the depression and coronary heart disease, LL genotype may be a protective factor for the depression and coronary heart disease.

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