Objective: To explore the relationships between cough reflex sensitivity and the neurokinin-1 receptor expression in lung in the gastroesophageal reflux model. Methods: We built the model and measured cough reflex sensitivity, observed neurokinin-1 receptor in lung by immunohistochemical staining. Results: The cough reflex sensitivity and the numbers of neurokinin-1 receptor-immunoreactive substances increased(108.48±25.71 vs 38.54±17.62, P<0.05)in the model group. Injected botulinum toxin-A into airway, the cough times dropped(23.33±7.53 vs 51.17±10.19, P<0.05), and the number of neurokinin-1 receptor also lowered(21.59±13.45 vs 108.48±25.71, P<0.05),but the cough latency was not significantly different(11.76±3.29 vs 8.24±4.73, P>0.05) compared to the model group. Conclusion: GERD increases the cough reflex sensitivity, and neurokinin-1 receptor in lung may play an important role in it.
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