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CT7:多发性骨髓瘤预后判断及治疗新方向
作者:张李玉1  欧阳建2  陈兵2 
单位:1. 东南大学医学院, 江苏 南京 210009;
2. 南京大学医学院附属南京鼓楼医院血液科, 江苏 南京 210008
关键词:多发性骨髓瘤 癌睾丸抗原 癌睾丸抗原7 文献综述 
分类号:R733.3;R730.5
出版年·卷·期(页码):2015·34·第四期(666-669)
摘要:

多发性骨髓瘤是难以治愈的骨髓恶性浆细胞增殖性疾病,严重威胁患者的生活质量。癌睾丸抗原(CTAs)是一类肿瘤相关性抗原,在多发性骨髓瘤细胞株以及多发性骨髓瘤患者骨髓标本中检测到多种CTAs表达,其中癌睾丸抗原7(CT7)的表达最为显著。研究发现 CT7表达阳性的患者临床预后相对较差,同时CT7有助于肿瘤细胞逃避凋亡,因此人们认为CT7有望成为靶向治疗的目标。

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