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椎间盘髓核细胞表型的研究进展
作者:蔡峰  吴小涛  王锋 
单位:东南大学医学院附属中大医院 脊柱外科, 江苏 南京 210009
关键词:椎间盘退变 髓核细胞表型 软骨细胞 脊索细胞 髓核祖细胞 文献综述 
分类号:R681.53
出版年·卷·期(页码):2015·34·第三期(443-447)
摘要:

髓核细胞特异性表型是识别髓核细胞和研究其生物学行为的基础,同时也是基因干预、细胞移植等生物学修复椎间盘退变的前提.髓核细胞兼有软骨细胞和脊索细胞的表型特点,而特定基因的转录和表达调控又广泛受到椎间盘局部微环境以及椎间盘退行性变的影响.部分髓核细胞亚群还具有祖细胞的生物学特性并表达特定的表型.对髓核细胞表型的研究有助于推动椎间盘退变生物学治疗的进展.

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