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转化生长因子β超家族对椎间盘退变影响的研究进展
作者:崔佳瞿1  吴小涛2 
单位:1. 东南大学医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 骨科, 江苏 南京 210009
关键词:椎间盘退变 转化生长因子β 文献综述 
分类号:R681.53
出版年·卷·期(页码):2015·34·第三期(439-443)
摘要:

椎间盘退变在临床上较为常见,是导致腰腿痛等病症的主要原因.椎间盘的退变源于椎间盘细胞数量减少以及细胞外基质的降解.目前尚无可以从根本上逆转椎间盘退变的方法.随着椎间盘退变分子机制研究的深入及分子生物学的发展,生长因子在椎间盘退变中所起的作用逐渐被发现,为椎间盘退变的治疗提供了新的视野和希望.近年来的研究证实转化生长因子β(TGF-β)与椎间盘退变密切相关,它可以通过促进椎间盘细胞增殖、增加细胞外基质合成、抑制基质降解酶等方面影响椎间盘退变.作者就TGF-β超家族对椎间盘退变的影响作一综述.

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