Objective: To explore the safety and reliability of Oro-Pharyngeal airway cap(OPLAC) in pediatric anesthesia. Methods: One hundred ASA Ⅰ or Ⅱ children scheduled for surgery were randomized to OPLAC group(O group) and tracheal intubation group(T group) with 50 cases each. Heat rate(HR), mean blood pressure(MAP), systolic blood pressure(SBP) and diastolic blood pressure(DBP), tidal volume(VT), pulse oxygen saturation(SpO₂) and end expiratory carbon dioxide pressure(P_ETCO₂) were recorded before intubation(T0), immediate after intubation(T1), 5 min after intubation(T2), before extubation(T3), immediate after extubation(T4), and 5 min after extubation(T5). The Success rate of insertion and ventilation satisfaction was also recorded. Results: Children with intubation success rate in O group was less than that in T group, there was no significantly difference(P >0.05). Set aside after the oral endotracheal tube in children with blood pressure in T group were significantly higher than those in O group, with significantly difference(P <0.05). Conclusion: OPLAC provides effective airway with less stress reaction compared with tradition tracheal intubation in anesthesia of children.