Objective: To investigate the clinical effect of patients with refractory heart failure treated with enteralnutrition intervention. Methods: 104 elderly patients with refractory heart failure were collected. They were randomly divided into observation group and control group, there were 52 cases in each group. The control group was treated with routine method for heart failure and liquid diet. The observation group was treated with enteralnutrition emulsion on basis of routine method for heart failure. The changes of body mass index (BMI), serum total protein (TP), albumin (ALB), hemoglobin (HB), brachial triceps skinfold thickness (TSF), arm muscle circumference(AMC), left ventricular ejection fraction(LVEF), interleukin(IL)-6, IL-8, tumor necrosis factor alpha (TNF-α) before treatment and at three months after treatment were compared. In addition,the occurrence of adverse events during treatment were observed in two groups. Results: BMI, TP, ALB, HB, TSF, SMC after treatment in the observation group were significantly higher than those in the control group(P <0.05). LVEF level of observation group after treatment was significantly higher than that of control group(P <0.05). The levels of IL-6 and TNF-α were significantly decreased (P <0.05). The incidence of adverse events of observation group was significantly lower than that of control group (P <0.05). Conclusion: There are different degree of malnutrition among most patients with refractory heart failure,so that except being done active anti heart failure treatment,the nutritional assessment should be done in these patients,and the nutrition intervention should be done in order to correct their nutritional status for malnutrition patients. The purpose is reducing inflammatory factor levels and inflammation to improve cardiac function, reduce the occurrence of complications, furtherly improve patients' prognosis.