Objective: To explore the efficacy and security of eddie-iodine oil emulsion interventional embolization of primary liver cancer. Methods:45 cases of patients with primary liver cancer who were hospitalized and were given interventional treatment in our hospital from January 2011 to June 2012, according to the random number table method, they were divided into group A (eddie-iodine oil treatment group), group B(anti-cancer drugs-iodine oil treatment group), group C (eddie+anti-cancer drugs-iodine oil treatment group), 15cases in each group, the clinical efficacy and security were compared of three groups. Results: The total effective rate of group C was 73.33%, higher than that of group A(66.67%) and group B(53.33%), but the differences of three groups had no statistical significance (P >0.05). 2 years survival rates of group A, B, C were respectively 33.33%,13.33%, 40.00%, the difference of three groups had no statistical significance(P >0.05). Incidences of poisonous adverse reaction of group A and group C were respectively 40.00%, 46.67%, the difference had no statistical significance of the two groups (P >0.05),but they were significantly lower than that of group B (80.00%), the difference both had statistical significance(P <0.05). Conclusion: Eddie-iodine oil emulsion can effectively improve the clinical efficacy of primary liver cancer of patients, it has the similar therapeutic effect with anti-cancer drugs-iodine oil emulsion, and it has synergistic therapeutic effect with anticancer drugs, it can reduce the poisonous adverse reaction of anti-cancer drug which produces, it can improve the quality of survive of patients.