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胰升糖素样肽-1在多囊卵巢综合征中的治疗前景
作者:刘杰  崔璨 
单位:哈尔滨医科大学附属第二医院 内分泌代谢病科, 黑龙江 哈尔滨 150000
关键词:多囊卵巢综合征 胰升糖素样肽-1类似物 胰岛素抵抗 综述 
分类号:R711.75
出版年·卷·期(页码):2015·34·第一期(143-147)
摘要:

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期妇女不孕的常见病因,然而其治疗却面临极大的挑战,因传统的药物及手术疗法常伴随一些严重的副作用。新型调节肠促胰素类降糖药物在PCOS中的应用越来越受到关注,其中胰升糖素样肽-1(glucagon-like peptide-1,GLP-1)类似物或其受体激动剂对POCS的治疗作用已得到广泛研究。GLP-1受体(GLP-1R)广泛表达于胰腺及胰腺外组织,GLP-1R分布的广泛性决定了其作用的多样性。GLP-1类似物及其受体激动剂对PCOS发病机制的多个环节进行干预,因此GLP-1类似物及其受体激动剂可能是未来PCOS患者的新选择。作者就PCOS近期研究进展作一综述。

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