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糖尿病与前列腺癌相关性研究
作者:李璐1  黄琼1  刘梦兰1  张日华1  刘云1  朱伟东2 
单位:1. 南京医科大学第一附属医院 老年内分泌科, 江苏 南京 210029;
2. 东南大学附属中大医院 泌尿外科, 江苏 南京 210009
关键词:前列腺癌 糖尿病 危险因素 病例对照研究 
分类号:R587.1;R737.25
出版年·卷·期(页码):2015·34·第一期(37-40)
摘要:

目的: 通过探究我国人群中前列腺癌患者与前列腺增生患者之间糖尿病发生率的差异来分析糖尿病与前列腺癌的相关性。方法:回顾性分析2006年至2013年间在我院住院治疗的1 271例年龄17~95岁汉族前列腺癌患者(前列腺癌组)的临床资料。对照组是随机选取的1 535例同期同一年龄段住院的前列腺增生患者。结果:前列腺癌组的糖尿病发病率为5.5%(70/1 271),显著低于前列腺增生组的7.8%(119/1 535,P=0.022)。前列腺癌组与前列腺增生组平均年龄差异无统计学意义(P>0.05)。单因素非条件性Logistic 回归分析显示,糖尿病与前列腺癌的发病率之间呈负相关性(OR=0.699; 95%CI:0.515,0.949)。结论:糖尿病可能是前列腺癌的保护性因素。

Objective: To study the incidence of diabetes mellitus between people with prostate cancer and prostatic hyperplasia, and analyze the relationship between diabetes mellitus and prostate cancer.Methods: A retrospective study was conducted in 1 271 prostate cancer patients from 2006 to 2013 in the First Affiliated Hospital of Nanjing Medical University.We randomly selected 1 535 diagnosis of prostatic hyperplasia patients as the control group. Results: The diabetes mellitus incidence in prostate cancer group was significantly lower than that in prostatic hyperplasia group (5.5% vs 7.8%, P=0.022). There was no statistical differences of age between the prostate cancer group and the prostatic hyperplasia group(P>0.05). The univariate and non-conditional Logistic regression model analysis showed that there had a negative correlation between diabetes mellitus and the incidence of prostate cancer(OR=0.699;95%CI:0.515, 0.949). Conclusion: Diabetes mellitus may be a protective factor of prostate cancer.

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